P16258

PR
Gene name
OSBP
Protein name
Oxysterol-binding protein 1
Names
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009048
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P16258

Entry ID Method Resolution Chain Position Source
AF-P16258-F1 Predicted AlphaFoldDB

No variants for P16258

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P16258

No associated diseases with P16258

2 regional properties for P16258

Type Name Position InterPro Accession
domain Pleckstrin homology domain 90 - 185 IPR001849
conserved_site Oxysterol-binding protein, conserved site 520 - 530 IPR018494

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Cytoplasm, perinuclear region
  • Golgi apparatus membrane ; Peripheral membrane protein
  • Endoplasmic reticulum membrane ; Peripheral membrane protein
  • Predominantly cytosolic
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

3 GO annotations of molecular function

Name Definition
cholesterol binding Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
phosphatidylinositol-4-phosphate binding Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
sterol transfer activity Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.

2 GO annotations of biological process

Name Definition
intracellular cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
sterol transport The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAATELRGVV GPGPAAIAAP GGGGAGPPVV GGGGGGRGDA GPGSGAASGT VAAAAAGGQG
70 80 90 100 110 120
PGAGGVAAAA GPAPTPPAGG SGSSGTGGSG SAREGWLFKW TNYIKGYQRR WFVLSNGLLS
130 140 150 160 170 180
YYRSKAEMRH TCRGTINLAT ANITVEDSCN FIISNGGAQT YHLKASSEVE RQRWVTALEL
190 200 210 220 230 240
AKAKAVKMLA ESDESGDEES VSQTDKTELQ NTLRTLSSKV EDLSTCNDLI AKHGTALQRS
250 260 270 280 290 300
LSELESLKLP AESNEKIKQV NERATLFRIT SNAMINACRD FLVLAQTHSK KWQKSLQYER
310 320 330 340 350 360
DQRIRLEETL EQLAKQHNHL ERAFRGATVL PAHTSGSAGS GKDQCCSGKG DMSDEDDENE
370 380 390 400 410 420
FFDAPEIITM PENLGHKRTG SNISGASSDI SLDEQYKHQL EETKKEKRTR IPYKPNYSLN
430 440 450 460 470 480
LWSIMKNCIG KELSKIPMPV NFNEPLSMLQ RLTEDLEYHE LLDRAAKCEN SLEQLCYVAA
490 500 510 520 530 540
FTVSSYSTTV FRTSKPFNPL LGETFELDRL EENGYRSLCE QVSHHPPAAA HHAESKNGWT
550 560 570 580 590 600
LRQEIKITSK FRGKYLSIMP LGTIHCIFHA TGHHYTWKKV TTTVHNIIVG KLWIDQSGEI
610 620 630 640 650 660
DIVNHKTGDK CNLKFVPYSY FSRDVARKVT GEVTDPSGKV HFALLGTWDE KMDCFKVQPV
670 680 690 700 710 720
SGENGGDARQ RGHEAEESRV MLWKRNPLPK NAENMYYFSE LALTLNAWEG GTAPTDSRLR
730 740 750 760 770 780
PDQRLMENGR WDEANAEKQR LEEKQRLSRK KREAEAMKAT EDGTPYDPYK ALWFERKKDP
790 800
VTKELTHIYR GEYWECKEKQ DWNSCPDIF