P16176

PR
Gene name
tgfb1
Protein name
Transforming growth factor beta-1 proprotein
Names
TGF-beta-5
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:397778
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P16176

Entry ID Method Resolution Chain Position Source
AF-P16176-F1 Predicted AlphaFoldDB

No variants for P16176

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P16176

No associated diseases with P16176

3 regional properties for P16176

Type Name Position InterPro Accession
domain TGF-beta, propeptide 23 - 250 IPR001111
domain Transforming growth factor-beta, C-terminal 267 - 382 IPR001839
conserved_site Transforming growth factor beta, conserved site 303 - 318 IPR017948

Functions

Description
EC Number
Subcellular Localization
  • [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

2 GO annotations of molecular function

Name Definition
growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
transforming growth factor beta receptor binding Binding to a transforming growth factor beta receptor.

2 GO annotations of biological process

Name Definition
positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of microglia differentiation Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEVLWMLLVL LVLHLSSLAM SLSTCKAVDM EEVRKRRIEA IRGQILSKLK LDKTPDVDSE
70 80 90 100 110 120
KMTVPSEAIF LYNSTLEVIR EKATREEEHV GHDQNIQDYY AKQVYRFESI TELEDHEFKF
130 140 150 160 170 180
KFNASHVREN VGMNSLLHHA ELRMYKKQTD KNMDQRMELF WKYQENGTTH SRYLESKYIT
190 200 210 220 230 240
PVTDDEWMSF DVTKTVNEWL KRAEENEQFG LQPACKCPTP QAKDIDIEGF PALRGDLASL
250 260 270 280 290 300
SSKENTKPYL MITSMPAERI DTVTSSRKKR GVGQEYCFGN NGPNCCVKPL YINFRKDLGW
310 320 330 340 350 360
KWIHEPKGYE ANYCLGNCPY IWSMDTQYSK VLSLYNQNNP GASISPCCVP DVLEPLPIIY
370 380
YVGRTAKVEQ LSNMVVRSCN CS