P16126
Gene name |
|
Protein name |
Bifunctional dihydrofolate reductase-thymidylate synthase |
Names |
DHFR-TS |
Species |
Leishmania amazonensis |
KEGG Pathway |
|
EC number |
1.5.1.3: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P16126
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P16126-F1 | Predicted | AlphaFoldDB |
No variants for P16126
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P16126 | |||||
No associated diseases with P16126
No regional properties for P16126
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P16126 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.5.1.3 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| dihydrofolate reductase activity | Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. |
| thymidylate synthase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| dTMP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| tetrahydrofolate biosynthetic process | The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRAAAKFKI | PMPVTKADFA | FPSLRAFSIV | VALDKQHGIG | DGESIPWRVP | EDMAFFKDQT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TLLRNKKPPT | DKKRNAVVMG | RKTWESVPVK | FRPLKGRLNV | VLSSKATVEE | LLAPLPEEKR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AAAAQDIVVV | NGGLAAAVRL | LARPPYCSSI | ETAYCVGGAQ | VYADAMLSPC | VEKLQEVYLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RIHTTAPACT | RFFPFPPENA | ATAWDLASSQ | GRRKSAVDGL | EFEICKYVPR | NHEERQYLEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IDRIMKTGIA | KEDRTGVGTL | SLFGAQMRFS | LRDNRLPLLT | TKRVFWRGVC | EELLWFLRGE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TNAQLLADKD | IHIWDGNGSR | EFLDSRGLTE | NTEMDLGPVY | GFQWRHFGAE | YRGLEANYDG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EGVDQIKFIV | ETIKANPNDR | RLLFTAWNPC | ALHKMALPPC | HLLAQFYVNT | EKSELSCMLY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QRSCDMGLGV | PFNIASYALL | TILIAKATGL | RPGELVHTLG | DAHVYRSHID | ALKAQLERVP |
| 490 | 500 | 510 | |||
| HAFPTLVFKE | ERQFLEDYEL | MDMEVIDYVP | HPPIKMEMAV |