P15691

PR
Gene name
VEGFA (VEGF)
Protein name
Vascular endothelial growth factor A
Names
VEGF-A, Vascular permeability factor, VPF
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281572
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

83-164 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P15691

Entry ID Method Resolution Chain Position Source
AF-P15691-F1 Predicted AlphaFoldDB

67 variants for P15691

Variant ID(s) Position Change Description Diseaes Association Provenance
rs469663585 24 S>A No EVA
rs445667018 24 S>C No EVA
rs477030299 25 Q>P No EVA
rs460281873 26 A>D No EVA
rs460281873 26 A>G No EVA
rs446523797 27 A>S No EVA
rs460988834 29 M>I No EVA
rs444150383 35 K>I No EVA
rs446524083 39 V>G No EVA
rs481121917 41 K>N No EVA
rs450615259 42 F>L No EVA
rs467550890 42 F>L No EVA
rs467550890 42 F>V No EVA
rs458821311 46 Y>S No EVA
rs446097074 47 Q>H No EVA
rs477377013 51 C>F No EVA
rs475086306 56 T>A No EVA
rs475086306 56 T>P No EVA
rs475086306 56 T>S No EVA
rs461556498 57 L>M No EVA
rs444618748 59 D>H No EVA
rs476141941 62 Q>* No EVA
rs432623303 63 E>D No EVA
rs452671317 63 E>G No EVA
rs472826096 64 Y>D No EVA
rs452748952 64 Y>F No EVA
rs472826096 64 Y>N No EVA
rs467485073 66 D>V No EVA
rs450636610 69 E>K No EVA
rs436974181 74 P>L No EVA
rs445176727 82 C>S No EVA
rs479667624 84 G>V No EVA
rs446831523 86 C>S No EVA
rs460540999 86 C>S No EVA
rs481615535 90 S>G No EVA
rs461439172 92 E>K No EVA
rs476072773 94 V>G No EVA
rs439068651 95 P>L No EVA
rs458947621 95 P>T No EVA
rs452835115 96 T>A No EVA
rs473942995 102 T>P No EVA
rs473942995 102 T>S No EVA
rs457001305 103 M>L No EVA
rs436849327 104 Q>R No EVA
rs457464198 113 S>I No EVA
rs474355522 115 H>Q No EVA
rs442929643 123 Q>H No EVA
rs453447008 124 H>R No EVA
rs473493889 129 C>W No EVA
rs440426786 140 N>S No EVA
rs442055841 142 C>R No EVA
rs384498513 143 G>W No EVA
rs478813572 171 C>* No EVA
rs462086557 171 C>F No EVA
rs447637645 175 Q>P No EVA
rs466690913 178 L>V No EVA
rs477375644 179 N>D No EVA
rs445949692 179 N>S No EVA
rs469117604 183 C>R No EVA
rs437800676 184 R>G No EVA
rs467360164 185 C>G No EVA
rs436153698 185 C>W No EVA
rs452885802 186 D>A No EVA
rs473114358 186 D>E No EVA
rs438363334 188 P>A No EVA
rs438363334 188 P>T No EVA
rs133889941 191 R>G No EVA

No associated diseases with P15691

3 regional properties for P15691

Type Name Position InterPro Accession
domain PDGF/VEGF domain 38 - 134 IPR000072
conserved_site Platelet-derived growth factor, conserved site 74 - 86 IPR023581
domain Vascular endothelial growth factor, heparin-binding domain 139 - 190 IPR027928

Functions

Description
EC Number
Subcellular Localization
  • Secreted
  • Secreted but remains associated to cells or to the extracellular matrix unless released by heparin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

8 GO annotations of molecular function

Name Definition
chemoattractant activity Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.
cytokine activity The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.
growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
protein homodimerization activity Binding to an identical protein to form a homodimer.
vascular endothelial growth factor receptor 1 binding Binding to a vascular endothelial growth factor receptor 1.
vascular endothelial growth factor receptor 2 binding Binding to a vascular endothelial growth factor receptor 2.
vascular endothelial growth factor receptor binding Binding to a vascular endothelial growth factor receptor.

17 GO annotations of biological process

Name Definition
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
induction of positive chemotaxis Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
motor neuron migration The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.
positive regulation of angiogenesis Any process that activates or increases angiogenesis.
positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of endothelial cell migration Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
positive regulation of endothelial cell proliferation Any process that activates or increases the rate or extent of endothelial cell proliferation.
positive regulation of focal adhesion assembly Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
positive regulation of mast cell chemotaxis Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus.
positive regulation of peptidyl-tyrosine phosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of protein-containing complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
sprouting angiogenesis The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
tube formation Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.
vascular endothelial growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
vascular endothelial growth factor signaling pathway The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9GKR0 VEGFA Vascular endothelial growth factor A Equus caballus (Horse) PR
Q00731 Vegfa Vascular endothelial growth factor A Mus musculus (Mouse) PR
P49151 VEGFA Vascular endothelial growth factor A Sus scrofa (Pig) PR
P16612 Vegfa Vascular endothelial growth factor A Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGQKPHEVV KFMDVYQRSF CRPIETLVDI
70 80 90 100 110 120
FQEYPDEIEF IFKPSCVPLM RCGGCCNDES LECVPTEEFN ITMQIMRIKP HQSQHIGEMS
130 140 150 160 170 180
FLQHNKCECR PKKDKARQEN PCGPCSERRK HLFVQDPQTC KCSCKNTDSR CKARQLELNE
RTCRCDKPRR