P15253

PR
Gene name
CALR
Protein name
Calreticulin
Names
HbREF, CRP55, Calregulin, Endoplasmic reticulum resident protein 60, ERp60, HACBP
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009050
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

182-297 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P15253

Entry ID Method Resolution Chain Position Source
AF-P15253-F1 Predicted AlphaFoldDB

1 variants for P15253

Variant ID(s) Position Change Description Diseaes Association Provenance
35 E>D No

No associated diseases with P15253

3 regional properties for P15253

Type Name Position InterPro Accession
conserved_site Calreticulin/calnexin, conserved site 98 - 113 IPR018124-1
conserved_site Calreticulin/calnexin, conserved site 130 - 138 IPR018124-2
conserved_site Calreticulin/calnexin, conserved site 242 - 254 IPR018124-3

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum lumen
  • Cytoplasm, cytosol
  • Secreted, extracellular space, extracellular matrix
  • Cell surface
  • Sarcoplasmic reticulum lumen
  • Cytoplasmic vesicle, secretory vesicle, Cortical granule
  • Cytolytic granule
  • Also found in cell surface (T cells), cytosol and extracellular matrix
  • During oocyte maturation and after parthenogenetic activation accumulates in cortical granules
  • In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity)
  • In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
cortical granule A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy.
cytolytic granule A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
sarcoplasmic reticulum A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
sarcoplasmic reticulum lumen The volume enclosed by the membranes of the sarcoplasmic reticulum.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
unfolded protein binding Binding to an unfolded protein.

2 GO annotations of biological process

Name Definition
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLLPVPLLLG LLGLAAAEPV VYFKEQFLDG DGWTERWIES KHKSDFGKFV LSSGKFYGDQ
70 80 90 100 110 120
EKDKGLQTSQ DARFYALSAR FEPFSNKGQP LVVQFTVKHE QNIDCGGGYV KLFPAGLDQK
130 140 150 160 170 180
DMHGDSEYNI MFGPDICGPG TKKVHVIFNY KGKNVLINKD IRCKDDEFTH LYTLIVRPDN
190 200 210 220 230 240
TYEVKIDNSQ VESGSLEDDW DFLPPKKIKD PDASKPEDWD ERAKIDDPTD SKPEDWDKPE
250 260 270 280 290 300
HIPDPDAKKP EDWDEEMDGE WEPPVIQNPE YKGEWKPRQI DNPDYKGTWI HPEIDNPEYS
310 320 330 340 350 360
PDANIYAYDS FAVLGLDLWQ VKSGTIFDNF LITNDEAYAE EFGNETWGVT KTAEKQMKDK
370 380 390 400 410
QDEEQRLKEE EEEKKRKEEE EAEEDEEDKD DKEDEDEDEE DKDEEEEEAA AGQAKDEL