P15122

PR
Gene name
AKR1B1
Protein name
Aldo-keto reductase family 1 member B1
Names
Aldehyde reductase, Aldose reductase, AR
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009122
EC number
1.1.1.300: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

182-264 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P15122

Entry ID Method Resolution Chain Position Source
AF-P15122-F1 Predicted AlphaFoldDB

No variants for P15122

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P15122

No associated diseases with P15122

4 regional properties for P15122

Type Name Position InterPro Accession
conserved_site Aldo/keto reductase, conserved site 39 - 56 IPR018170-1
conserved_site Aldo/keto reductase, conserved site 145 - 162 IPR018170-2
conserved_site Aldo/keto reductase, conserved site 261 - 276 IPR018170-3
domain NADP-dependent oxidoreductase domain 16 - 289 IPR023210

Functions

Description
EC Number 1.1.1.300 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

6 GO annotations of molecular function

Name Definition
alditol:NADP+ 1-oxidoreductase activity Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
allyl-alcohol dehydrogenase activity Catalysis of the reaction: allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.
glycerol dehydrogenase [NADP+] activity Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH.
NADP-retinol dehydrogenase activity Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
prostaglandin H2 endoperoxidase reductase activity Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).
retinal dehydrogenase activity Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.

1 GO annotations of biological process

Name Definition
retinoid metabolic process The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATHLVLYNG AKMPILGLGT WKSPPGQVTE AVKTAIDLGY RHIDCAHVYQ NENEVGVALQ
70 80 90 100 110 120
EKLKEQVVKR EELFIVSKLW CTSHDKSLVK GACQKTLNDL KLDYLDLYLI HWPTGFKHGS
130 140 150 160 170 180
EYFPLDAAGN VIPSDTDFLD TWEAMEGLVD EGLVKSIGVS NFNHLQIERI LNKPGLKYKP
190 200 210 220 230 240
AVNQIECHPY LTQEKLIQYC HSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIADK
250 260 270 280 290 300
HKKTTAQVLI RFPMQRNLVV IPKSVTPARI AENFQVFDFE LSSEDMTTLL SYNRNWRVCA
310
LVSCASHKDY PFHAEF