P14953

PR
Gene name
trpE
Protein name
Anthranilate synthase component 1
Names
AS, ASI
Species
Acetivibrio thermocellus (Hungateiclostridium thermocellum) (Clostridium thermocellum)
KEGG Pathway
EC number
4.1.3.27: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

171-247 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P14953

Entry ID Method Resolution Chain Position Source
AF-P14953-F1 Predicted AlphaFoldDB

No variants for P14953

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P14953

No associated diseases with P14953

2 regional properties for P14953

Type Name Position InterPro Accession
domain Anthranilate synthase component I, N-terminal 28 - 168 IPR006805
domain Chorismate-utilising enzyme, C-terminal 225 - 479 IPR015890

Functions

Description
EC Number 4.1.3.27 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
anthranilate synthase activity Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFYPTLDEVK IMAKDYNIIP VTMEVYADME TPISLFKRFE ESSCCFLLES VEGGEKWARY
70 80 90 100 110 120
SIIGKNPFLV VESYKNKTII RERNGSQREV EGNPVEIIKG IMGKFKGANL PNLPRFNGGA
130 140 150 160 170 180
VGYFGYDLIR HYENLPNVPE DDMGLPECHF MFTDEVLVYD HLKQKIHIIV NLHVNGNIER
190 200 210 220 230 240
AYISAVDRIK TIHREILDTR WKTADNSVLS YNKKKNELAV TSNISKEDFC RNVLKAKQYI
250 260 270 280 290 300
RDGDIFQVVL SQRLCVETNE NPFNIYRALR VINPSPYMYY LKFGGYRIIG SSPEMLVRVE
310 320 330 340 350 360
NGIVETCPIA GTRKRGRTKE EDEALEKELL SDEKEIAEHV MLVDLGRNDI GRVSKFGTVA
370 380 390 400 410 420
VKNLMHIERY SHVMHVVTNV QGEIREDKTP FDALMSILPA GTLSGAPKVR AMEIIDELET
430 440 450 460 470 480
VKRGPYGGAI GYLSFNGNLD SCITIRTIIL KDGKAYVQAG AGIVADSVPE REYEECYNKA
490
MALLKAIEEA GEIR