Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P14885
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P14885-F1 | Predicted | AlphaFoldDB |
No variants for P14885
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P14885 | |||||
No associated diseases with P14885
3 regional properties for P14885
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Gelsolin-like domain | 93 - 171 | IPR007123-1 |
| domain | Gelsolin-like domain | 213 - 261 | IPR007123-2 |
| domain | Gelsolin-like domain | 316 - 392 | IPR007123-3 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament severing | The process in which an actin filament is broken down into smaller filaments. |
| actin nucleation | The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. |
| barbed-end actin filament capping | The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. |
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| FISKMGYPKQ | TQVQVLPESG | ETPLFKQFFK | NWRDKEATDG | MGVAYVPNHI | AKIENVPFDV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVLHESPAMA | AQHGMVDDGS | GKKQIWRIEN | CEKVPVLESH | YGQFYGGDSY | IILYHYKSGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KQGQIIYTWQ | GDDSTKDEIT | ASAILSAQLD | EELGGGPVQV | RVVQGKEPAH | LISLFGGKPM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IIYKGGTSRE | GGQTKDANVR | LFQVRTSSSG | FSRAVEVDNT | ASNLNSNDAF | VLTTPSASYL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WVGQGSTNVE | KNGAKELLKI | LGVSASEIPE | GQETDDFWGA | LGGKADYRTS | ARLKDKLNAH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PPRLFACSNK | TGRFIIEEVP | GEISQDDLAT | DDVMLLDTWD | QVYVWVGNEA | QEDEKKEAIA |
| 370 | 380 | 390 | 400 | 410 | |
| SAYKYIESDP | ANRDKRTPVA | ITKQGFEPPT | FIGWFLGWEA | DYWDVDPLER | AMAGLSS |