P14829

PR
Gene name
gyrA
Protein name
DNA gyrase subunit A
Names
Species
Klebsiella oxytoca
KEGG Pathway
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

811-876 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P14829

Entry ID Method Resolution Chain Position Source
AF-P14829-F1 Predicted AlphaFoldDB

No variants for P14829

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P14829

No associated diseases with P14829

7 regional properties for P14829

Type Name Position InterPro Accession
domain DNA topoisomerase, type IIA, domain A 11 - 506 IPR002205
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 537 - 583 IPR006691-1
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 587 - 634 IPR006691-2
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 644 - 687 IPR006691-3
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 691 - 736 IPR006691-4
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 743 - 788 IPR006691-5
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 792 - 838 IPR006691-6

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA negative supercoiling activity Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDLAREITP VNIEEELKSS YLDYAMSVIV GRALPDVRDG LKPVHRRVLY AMNVLGNDWN
70 80 90 100 110 120
KAYKKSARVV GDVIGKYHPH GDTAVYDTIV RMAQPFSLRY MLVDGQGNFG SVDGDSAAAM
130 140 150 160 170 180
RYTEIRMSKI AHELMADLEK ETVDFVDNYD GTEKIPDVMP TKIPNLLVNG SFGIAVGMAT
190 200 210 220 230 240
NIPPHNLTEV INGRLAYVED EEISIEGLME HIPGPDFPTA AIINGRRGIE EAYRTGRGKV
250 260 270 280 290 300
YICARAEVEA DAKTGRETII VHEIPYQVNK ARLIEKIAEL VKEKRVEGIS ALRDESDKDG
310 320 330 340 350 360
MRIVIEVKRD AVGRVVLNNL YSQTQLQVSF GINMVALHHG QPKIMNLKEI IAAFVRHRRE
370 380 390 400 410 420
VVTRRTILAL RKARDRADIL EALSIALANI DPIIELIRRA PTPAEAKAGL IARSWDLGNV
430 440 450 460 470 480
SAMLEAGDDA ARPEWLEPEF GVRDGQYYLT EQQAQAILDL RLQKLTGLEH EKLLDEYKEL
490 500 510 520 530 540
LEQIAELLHI LGSADRLMEV IREELELVRE QFGDARRTDI TANSVDINIE DLITQEDVVV
550 560 570 580 590 600
TLSHEGYVKY QPVNDYEAQR RGGKGKSAPR IKEEDFIDRL LVANTHDTIL CFSSRGRLYW
610 620 630 640 650 660
MKVYQVPEAS RGARGRPIVN LLPLEANERY TAILPVREYE EGVNVFMATA SGTVKKTPAD
670 680 690 700 710 720
EFSRPRSAGI IAVNLNEGDE LIGVDLTSGQ DEVMLFSAAG KVVRFKEDDV RAMGRTATGV
730 740 750 760 770 780
RGIKLAGEDK VVSLIVPRGE GRILTATENG YRKRTAVAEY PTKSRATQGV ISIKVTERNG
790 800 810 820 830 840
SVVGAVQVDD CDQIMMITDA GTLVRIRVSE VSIVGRNTQG VILIRTAEDE NVVALQRVAE
850 860 870
PVDDEELDAI DGSAAEGDED IAPEADTDDD IAEDEE