P14611

PR
Gene name
phaA
Protein name
Acetyl-CoA acetyltransferase
Names
Acetoacetyl-CoA thiolase, Beta-ketothiolase
Species
Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha)
KEGG Pathway
reh:H16_A1438
EC number
2.3.1.9: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

87-157 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P14611

Entry ID Method Resolution Chain Position Source
4O99 X-ray 196 A A/B/C/D 2-393 PDB
4O9A X-ray 152 A A/B/C/D 2-393 PDB
4O9C X-ray 200 A A/B/C/D/E/F/G/H 1-393 PDB
AF-P14611-F1 Predicted AlphaFoldDB

No variants for P14611

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P14611

No associated diseases with P14611

5 regional properties for P14611

Type Name Position InterPro Accession
active_site Thiolase, active site 374 - 387 IPR020610
conserved_site Thiolase, conserved site 339 - 355 IPR020613
active_site Thiolase, acyl-enzyme intermediate active site 84 - 102 IPR020615
domain Thiolase, N-terminal 4 - 262 IPR020616
domain Thiolase, C-terminal 270 - 392 IPR020617

Functions

Description
EC Number 2.3.1.9 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
acetyl-CoA C-acetyltransferase activity Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.

1 GO annotations of biological process

Name Definition
poly-hydroxybutyrate biosynthetic process The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDVVIVSAA RTAVGKFGGS LAKIPAPELG AVVIKAALER AGVKPEQVSE VIMGQVLTAG
70 80 90 100 110 120
SGQNPARQAA IKAGLPAMVP AMTINKVCGS GLKAVMLAAN AIMAGDAEIV VAGGQENMSA
130 140 150 160 170 180
APHVLPGSRD GFRMGDAKLV DTMIVDGLWD VYNQYHMGIT AENVAKEYGI TREAQDEFAV
190 200 210 220 230 240
GSQNKAEAAQ KAGKFDEEIV PVLIPQRKGD PVAFKTDEFV RQGATLDSMS GLKPAFDKAG
250 260 270 280 290 300
TVTAANASGL NDGAAAVVVM SAAKAKELGL TPLATIKSYA NAGVDPKVMG MGPVPASKRA
310 320 330 340 350 360
LSRAEWTPQD LDLMEINEAF AAQALAVHQQ MGWDTSKVNV NGGAIAIGHP IGASGCRILV
370 380 390
TLLHEMKRRD AKKGLASLCI GGGMGVALAV ERK