P14605

PR
Gene name
cyr1 (SPBC19C7.03)
Protein name
Adenylate cyclase
Names
ATP pyrophosphate-lyase, Adenylyl cyclase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC19C7.03
EC number
4.6.1.1: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

79-167 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P14605

Entry ID Method Resolution Chain Position Source
AF-P14605-F1 Predicted AlphaFoldDB

No variants for P14605

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P14605

No associated diseases with P14605

17 regional properties for P14605

Type Name Position InterPro Accession
domain Ras-associating domain 292 - 380 IPR000159
domain Adenylyl cyclase class-3/4/guanylyl cyclase 1261 - 1537 IPR001054
repeat Leucine-rich repeat 476 - 547 IPR001611-1
repeat Leucine-rich repeat 549 - 570 IPR001611-2
repeat Leucine-rich repeat 596 - 617 IPR001611-3
repeat Leucine-rich repeat 806 - 866 IPR001611-4
domain PPM-type phosphatase-like domain 985 - 1275 IPR001932
repeat Leucine-rich repeat, typical subtype 475 - 498 IPR003591-1
repeat Leucine-rich repeat, typical subtype 524 - 546 IPR003591-2
repeat Leucine-rich repeat, typical subtype 547 - 569 IPR003591-3
repeat Leucine-rich repeat, typical subtype 570 - 593 IPR003591-4
repeat Leucine-rich repeat, typical subtype 594 - 616 IPR003591-5
repeat Leucine-rich repeat, typical subtype 682 - 705 IPR003591-6
repeat Leucine-rich repeat, typical subtype 728 - 751 IPR003591-7
repeat Leucine-rich repeat, typical subtype 829 - 852 IPR003591-8
repeat Leucine-rich repeat, typical subtype 853 - 876 IPR003591-9
domain Adenylate cyclase G-alpha binding 155 - 200 IPR013716

Functions

Description
EC Number 4.6.1.1 Phosphorus-oxygen lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
adenylate cyclase activity Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
manganese ion binding Binding to a manganese ion (Mn).
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

5 GO annotations of biological process

Name Definition
adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by glucose binding to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process.
cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of induction of conjugation with cellular fusion Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion.
negative regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDQSKRLLKS AVPNPPEHFK TGISWLDDLD EKDDDSATSV NYDIPEITEA NLCNDSHEAL
70 80 90 100 110 120
SPCTQPVGNS GRPVEAFKTY PSTPAVPSKS VLFHFYEPDE NFSLSDTGRT KSDTALAARE
130 140 150 160 170 180
SSEKSEVPRD TRSAGIKPYK ENNSSNCAIS KEAGLRRLID KDRESFDKNL NQSFTNLTFP
190 200 210 220 230 240
EPISDDSDSV EFQRDSLNNN WPASLEGSIH ELPRNSDDDG IPASAAHILD LDYHRDSYDS
250 260 270 280 290 300
PWKKFLPYPS ILSDDSWKAP ESWGTSLPTE AIPKQVFTTR FFARPSLGNR KKEFFLRVYR
310 320 330 340 350 360
DDRTSVSFIC PIGIQTHEVI KLLARLFFLP SSANFYLLLI QFNTERILLP HEQPCIIFER
370 380 390 400 410 420
LLSLFGCKVT SDEEINEEDN YSVARLVFTT MDIGADVLRK FSEKKITANL DISRSNLEVI
430 440 450 460 470 480
PVKIYPYAHE LISLNVSHNL SLDLPLDFME RCVKLKRLDI SNNLRSPRGK PITALRQLEV
490 500 510 520 530 540
LNMSRNDIYE LDPLIFSGLS RNSLKELNIA NNKLFFLPHS TRYLVNLTYL DLSYNNFVTF
550 560 570 580 590 600
PLIITELSQL ETLNFSHNLL SQISSKIGSL VKLKHLYLQF NDLSNRLPQE IGLLKNLETI
610 620 630 640 650 660
DLSYNAITNI ASLSECPKLN SINVACNLLS FYEYSNPSAT FIDFSFCPLT TIDPAFSYSN
670 680 690 700 710 720
LVYFDISHAK LIGLKDSVIE TLVNVETVKV NYNHFTSISD AISAMQNLKY LSCTNCEMSY
730 740 750 760 770 780
VSPNLGKLKH LVHLDLHANN IKIFPEEVWQ VSSLKVVNLS SNILEKIKLP VATSKKLTRT
790 800 810 820 830 840
ISQLKIMRTL SGNPVSSLSS QEFVMPTVEE LYLVDNRLGN DCFTALEYFK CLKVLNLSYN
850 860 870 880 890 900
YLTEIPSKFF QNFSDLKHLF VSGNELANLS ISSTAQVLLE TLYANGNRLS SFPKNEALSK
910 920 930 940 950 960
SLRFLDISTN NLQNLAVEKA EKKSLTKLPQ LEYLNLSGNT WFRFSEHEDT NFTKSYLKNL
970 980 990 1000 1010 1020
KFLSIMDLNT KFSNAPSDVL NHFIQRNSPQ PNILRYGVCG YLSRSIPVIS ACELVVNNFL
1030 1040 1050 1060 1070 1080
HPQSSLYCVL DSDISAGKNN RVLKFVYDNL ASCLAHEINA ADSSSEQICN ALRRGFLRLN
1090 1100 1110 1120 1130 1140
KKLGNVIHYD LRKSSEGDVD SNYVTTMNIS EKGYSMDSSC LDIGVSIILV YVRDTRAFVA
1150 1160 1170 1180 1190 1200
NVGTSMAIMS TRNDSEPTTL SVMHDVYNRD EIRRIVDSCG FISGEIKSTT TRAIGRLSQF
1210 1220 1230 1240 1250 1260
PGVQAVPYVN VQYLSELNEF IILANQEFWS VLSKRTVIDV VRANRHSPLL ASTKLRDYAI
1270 1280 1290 1300 1310 1320
AYGAEKNVLV VIVELNGLFE ENSLNFNQLR GDEKTLAISE KNDNMSFVQD LPDDSSLARM
1330 1340 1350 1360 1370 1380
NREVSPPKGC IAMVFTDIKN STLLWERHPI AMRSAIKTHN TIMRRQLRAT GGYEVKTEGD
1390 1400 1410 1420 1430 1440
AFMVCFQTVP AALLWCFSVQ LQLLSADWPN EIVESVQGRL VLGSKNEVLY RGLSVRIGVN
1450 1460 1470 1480 1490 1500
YGVTVSELDP ITRRMDYYGP VVNRTSRVVS VADGGQIAVS AEVVSVLNQL DSETMSSEKT
1510 1520 1530 1540 1550 1560
NVNEMEVRAL KQIGYIIHNL GEFKLKGLDT TEMISLVYPV QLQGRLERLI KSRSLGTPTA
1570 1580 1590 1600 1610 1620
LPETQTYTPV RSRSNSLRPM LARLSDSKSV HGEEGGSGKR SVSSLRNVSP SESTGGYEGC
1630 1640 1650 1660 1670 1680
IFDDQQYQLL YELCERLEDH AAILHGFPEP PPCDTGLAAP VNQAEEYSLF YRLTLRIENT
1690
IYCVSQMLGH TG