P14581
Gene name |
CYP4A7 |
Protein name |
Cytochrome P450 4A7 |
Names |
CYPIVA7, Cytochrome P450-KA-2, Lauric acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase |
Species |
Oryctolagus cuniculus (Rabbit) |
KEGG Pathway |
ocu:100328944 |
EC number |
1.14.14.80: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P14581
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P14581-F1 | Predicted | AlphaFoldDB |
No variants for P14581
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P14581 | |||||
No associated diseases with P14581
1 regional properties for P14581
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 451 - 460 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.80 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| long-chain fatty acid omega-hydroxylase activity | Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVSALSSTR | LPGSFSGFLQ | AAALLGLLLL | LLKAAQLYLR | RQWLLRALQQ | FPCPPSHWLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GHSREFPIDS | ELQQVLKRVE | KFPSACPRWL | WGSELFLICY | DPDYMKTILG | RSDPKARVSY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SFLAPWIGYG | LLLLEGQTWF | QHRRMLTPAF | HYDILKPYVG | LMVDSVQVML | DKLEKLARKD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| APLEIYEHVS | LMTLETIMKC | AFSHQGSVQL | ESRTSKSYIQ | AVRELSDLAL | QRVRNVFHQS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DFLYRLSPEG | RLSHRACQLA | HEHTDRVIQQ | RKAQLQQEGE | LEKVRRKRRL | DFLDVLLFAK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MENGSSLSDQ | DLRAEVDTFM | FEGHDTTASG | ISWIFYALAT | HPEHQHRCRE | EIQGLLGDGA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SITWEHLDKM | PYTTMCIKEA | LRLYPPVPGV | GSKLSSPVTF | PDGRSLPKGI | IITLSIYGLH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HNPKVWPNPE | VFDPSRFAPG | SARHSHAFLP | FSGGSRNCIG | KQFAMNELKV | AVALTLVRFE |
| 490 | 500 | 510 | |||
| LLPDPTRVPI | PITRLVLKSK | NGIHLRLRKL | H |