P14580
Gene name |
CYP4A6 |
Protein name |
Cytochrome P450 4A6 |
Names |
CYPIVA6, Cytochrome P450-KA-1, Lauric acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase |
Species |
Oryctolagus cuniculus (Rabbit) |
KEGG Pathway |
ocu:100328946 |
EC number |
1.14.14.80: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P14580
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P14580-F1 | Predicted | AlphaFoldDB |
No variants for P14580
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P14580 | |||||
No associated diseases with P14580
1 regional properties for P14580
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 450 - 459 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.80 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| long-chain fatty acid omega-hydroxylase activity | Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVSALNPTR | LPGSLSGLLQ | VAGLLGLLLL | LLKAAQLYLH | RQWLLRALQQ | FPCPPFHWLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GHSREFQNGH | ELQVMLKWVE | KFPSACPRWL | WGSRAHLLIY | DPDYMKVILG | RSDPKAQGSY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RFLAPWIGYG | LLLLNGQTWF | QHRRMLTPAF | HYDILKPYVG | LMADSVQIML | DKWEQLVSQD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSLEVFQDIS | LMTLDTIMKC | AFSHQGSVQL | DRNSQSYIQA | VGDLNNLFFS | RVRNVFHQSD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TIYRLSPEGR | LSHRACQLAH | EHTDRVIQQR | KAQLQQEGEL | EKVRRKRRLD | FLDVLLFAKM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ENGSSLSDQD | LRAEVDTFMF | EGHDTTASGI | SWIFYALATH | PEHQHRCREE | IQGLLGDGAS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ITWEHLDQMP | YTTMCIKEAL | RLYPPVPGVG | RQLSSPVTFP | DGRSLPKGVI | VTLSIYALHH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NPKVWPNPEV | FDPFPFAPGS | ARHSHAFLPF | SGGPRNCIGK | QFAMNELKVA | VALTLVRFEL |
| 490 | 500 | ||||
| LPDPKRVPDQ | KPRLVLKSSN | GIHLRLRKLR |