Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P13908
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P13908-F1 | Predicted | AlphaFoldDB |
No variants for P13908
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P13908 | |||||
No associated diseases with P13908
4 regional properties for P13908
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Neurotransmitter-gated ion-channel transmembrane domain | 242 - 355 | IPR006029-1 |
| domain | Neurotransmitter-gated ion-channel transmembrane domain | 374 - 446 | IPR006029-2 |
| domain | Neurotransmitter-gated ion-channel ligand-binding domain | 32 - 234 | IPR006202 |
| conserved_site | Neurotransmitter-gated ion-channel, conserved site | 155 - 169 | IPR018000 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetylcholine-gated cation-selective channel activity | Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. |
| transmembrane signaling receptor activity | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTLAVIGLFT | LFTSIIAITP | AREFVSLAER | EDALLRELFQ | GYQRWVRPVQ | HANHSVKVRF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GLKISQLVDV | DEKNQLMTTN | VWLWQEWLDY | KLRWNPENYG | GITSIRVPSE | SIWLPDIVLY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ENADGRFEGS | LMTKAIVRYN | GMITWTPPAS | YKSACTMDVT | FFPFDRQNCS | MKFGSWTYDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NMVKLVLINQ | QVDRSDFFDN | GEWEILSATG | VKGSRQDSHL | SYPYITYSFI | LKRLPLFYTL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLIIPCLGLS | FLTVLVFYLP | SDEGEKVSLS | TSVLVSLTVF | LLVIEEIIPS | SSKVIPLIGE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YLLFIMIFVT | LSIIVTIFVI | NVHHRSSATY | HPMSPWVRSL | FLQRLPHLLC | MRGNTDRYHY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PELEPHSPDL | KPRNKKGPPG | PEGEGQALIN | LLEQATNSVR | YISRHIKKEH | FIREVVQDWK |
| 430 | 440 | 450 | 460 | ||
| FVAQVLDRIF | LWTFLTVSVL | GTILIFTPAL | KMFLRTPPPP | SP |