P13563
Gene name |
has1 |
Protein name |
Hyaluronan synthase 1 |
Names |
DG42 protein, Hyaluronate synthase 1, Hyaluronic acid synthase 1, HA synthase 1, xHAS1 |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:379383 |
EC number |
2.4.1.212: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P13563
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P13563-F1 | Predicted | AlphaFoldDB |
No variants for P13563
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P13563 | |||||
No associated diseases with P13563
No regional properties for P13563
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P13563 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.212 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| hyaluronan synthase activity | Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| extracellular matrix assembly | The aggregation, arrangement and bonding together of the extracellular matrix. |
| extracellular polysaccharide biosynthetic process | The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. |
| hyaluronan biosynthetic process | The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKEKAAETME | IPEGIPKDLE | PKHPTLWRII | YYSFGVVLLA | TITAAYVAEF | QVLKHEAILF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLGLYGLAML | LHLMMQSLFA | FLEIRRVNKS | ELPCSFKKTV | ALTIAGYQEN | PEYLIKCLES |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CKYVKYPKDK | LKIILVIDGN | TEDDAYMMEM | FKDVFHGEDV | GTYVWKGNYH | TVKKPEETNK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GSCPEVSKPL | NEDEGINMVE | ELVRNKRCVC | IMQQWGGKRE | VMYTAFQAIG | TSVDYVQVCD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SDTKLDELAT | VEMVKVLESN | DMYGAVGGDV | RILNPYDSFI | SFMSSLRYWM | AFNVERACQS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YFDCVSCISG | PLGMYRNNIL | QVFLEAWYRQ | KFLGTYCTLG | DDRHLTNRVL | SMGYRTKYTH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KSRAFSETPS | LYLRWLNQQT | RWTKSYFREW | LYNAQWWHKH | HIWMTYESVV | SFIFPFFITA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TVIRLIYAGT | IWNVVWLLLC | IQIMSLFKSI | YACWLRGNFI | MLLMSLYSML | YMTGLLPSKY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FALLTLNKTG | WGTSGRKKIV | GNYMPILPLS | IWAAVLCGGV | GYSIYMDCQN | DWSTPEKQKE |
| 550 | 560 | 570 | 580 | ||
| MYHLLYGCVG | YVMYWVIMAV | MYWVWVKRCC | RKRSQTVTLV | HDIPDMCV |