P13510

PR
Gene name
czcB (Rmet_5981)
Protein name
Cobalt-zinc-cadmium resistance protein CzcB
Names
Cation efflux system protein CzcB
Species
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
KEGG Pathway
rme:Rmet_5981
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-220 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P13510

Entry ID Method Resolution Chain Position Source
AF-P13510-F1 Predicted AlphaFoldDB

No variants for P13510

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P13510

No associated diseases with P13510

2 regional properties for P13510

Type Name Position InterPro Accession
domain RND efflux pump, membrane fusion protein, barrel-sandwich domain 205 - 435 IPR032317
domain Cation efflux system protein CusB, domain 1 195 - 500 IPR043602

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Single-pass membrane protein
  • May be anchored in the inner membrane, cross the periplasm and contact the outer membrane as proposed for membrane fusion proteins
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
metal ion transmembrane transporter activity Enables the transfer of metal ions from one side of a membrane to the other.

1 GO annotations of biological process

Name Definition
response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAISNKQKAA IAAIVLVGGV ATGGVLLSGR SAPEEQGGHS ESKGHGDTEH HGKQAAEADH
70 80 90 100 110 120
KDDKSHGDGE HHEVKKGPNG GALFSRDGYD VEIGTAESKG EARIRLWVSK SGKAVANGVA
130 140 150 160 170 180
ATGQLVRATG ESQALKFVVS GDALESQQPV AEPHVFDVTA NVTLPGSSSP LAVRLSKEEG
190 200 210 220 230 240
KIELTADQLA KTGVVVQTAG SAKVQAGVQF PGEIRFNEDK TAHVVPRLAG VVESVPANIG
250 260 270 280 290 300
QQVKKGQVLA VIASTGLSDQ RSELLAAQKR LDLARVTYDR EKKLWEQKIS AEQDYLSARN
310 320 330 340 350 360
ALQEAQISVQ NAQQKLTAIG ASNSSTALNR YELRAPFDGM IVEKHISLGE AVADNANVFT
370 380 390 400 410 420
LSDLSSVWAE FVVSAKDVER VRIGEKASIN SASSDVKADG TVSYVGSLLG EQTRTAKARV
430 440 450 460 470 480
TLTNPQMAWR PGLFVTVDVF GADVEVPVAV KTEAVQDVNG ESVVFVAVQG GFVPQPVKVG
490 500 510
RTNGKVIEIV EGLKPGARYA AANSFVLKAE LGKSSAEHGH