P13491

PR
Gene name
LDHA
Protein name
L-lactate dehydrogenase A chain
Names
LDH-A, LDH muscle subunit, LDH-M
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009107
EC number
1.1.1.27: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

11 structures for P13491

Entry ID Method Resolution Chain Position Source
3H3F X-ray 238 A A/B/C/D/E/F/G/H 2-332 PDB
4I8X X-ray 223 A A/B/C/D/E/F/G/H 2-332 PDB
4I9H X-ray 217 A A/B/C/D/E/F/G/H 2-332 PDB
4I9N X-ray 235 A A/B/C/D/E/F/G/H 2-332 PDB
4I9U X-ray 250 A A/B/C/D/E/F/G/H 2-332 PDB
5KKC X-ray 186 A A/B/C/D 2-332 PDB
5NQB X-ray 158 A A/B/C/D 1-332 PDB
5NQQ X-ray 187 A A/B/C/D 1-332 PDB
6P6U X-ray 242 A A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 1-332 PDB
7P4G X-ray 260 A A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 1-332 PDB
AF-P13491-F1 Predicted AlphaFoldDB

No variants for P13491

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P13491

No associated diseases with P13491

3 regional properties for P13491

Type Name Position InterPro Accession
domain Lactate/malate dehydrogenase, N-terminal 22 - 160 IPR001236
active_site L-lactate dehydrogenase, active site 190 - 196 IPR018177
domain Lactate/malate dehydrogenase, C-terminal 164 - 324 IPR022383

Functions

Description
EC Number 1.1.1.27 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.

1 GO annotations of biological process

Name Definition
lactate metabolic process The chemical reactions and pathways involving lactate, the anion of lactic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAALKDQLIH NLLKEEHVPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVMEDKLKG
70 80 90 100 110 120
EMMDLQHGSL FLRTPKIVSG KDYSVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI
130 140 150 160 170 180
IPNVVKYSPH CKLLVVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV
190 200 210 220 230 240
HALSCHGWIL GEHGDSSVPV WSGMNVAGVS LKTLHPELGT DADKEQWKQV HKQVVDSAYE
250 260 270 280 290 300
VIKLKGYTTW AIGLSVADLA ESIMKNLRRV HPISTMLKGL YGIKEDVFLS VPCVLGQNGI
310 320 330
SDVVKVTLTS EEEAHLKKSA DTLWGIQKEL QF