P12965

PR
Gene name
mos
Protein name
Serine/threonine-protein kinase mos
Names
pp39-mos
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:397924
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-78 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

206-221 (Activation loop from InterPro)

Target domain

63-336 (Protein kinase domain)

Relief mechanism

Assay

232-238 (Activation loop from InterPro)

Target domain

63-336 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P12965

Entry ID Method Resolution Chain Position Source
AF-P12965-F1 Predicted AlphaFoldDB

No variants for P12965

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P12965

No associated diseases with P12965

7 regional properties for P12965

Type Name Position InterPro Accession
conserved_site Quinoprotein dehydrogenase, conserved site 45 - 73 IPR001479-1
conserved_site Quinoprotein dehydrogenase, conserved site 275 - 296 IPR001479-2
repeat Pyrrolo-quinoline quinone repeat 87 - 235 IPR002372
repeat Pyrrolo-quinoline quinone beta-propeller repeat 149 - 180 IPR018391-1
repeat Pyrrolo-quinoline quinone beta-propeller repeat 194 - 231 IPR018391-2
repeat Pyrrolo-quinoline quinone beta-propeller repeat 456 - 501 IPR018391-3
repeat Pyrrolo-quinoline quinone beta-propeller repeat 510 - 542 IPR018391-4

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

2 GO annotations of biological process

Name Definition
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSPIPVERF LPRDLSPSID LRPCSSPLEL SHRKLPGGLP ACSGRPRLLP PRLAWCSIDW
70 80 90 100 110 120
EQVLLLEPLG SGGFGSVYRA TYRGETVALK KVKRSTKNSL ASRQSFWAEL NAARLRHPHV
130 140 150 160 170 180
VRVVAASASC PGDPGCPGTI IMEYTGTGTL HQRIYGRSPP LGAEICMRYA RHVADGLRFL
190 200 210 220 230 240
HRDGVVHLDL KPANVLLAPG DLCKIGDFGC SQRLREGDEA AGGEPCCTQL RHVGGTYTHR
250 260 270 280 290 300
APELLKGEPV TAKADIYSFA ITLWQMVSRE LPYTGDRQCV LYAVVAYDLR PEMGPLFSHT
310 320 330 340 350
EEGRAARTIV QSCWAARPQE RPNAEQLLER LEQECAMCTG GPPSCSPESN APPPLGTGL