P12905

PR
Gene name
Protein name
Large T antigen
Names
LT, LT-AG
Species
Murine polyomavirus (strain Crawford small-plaque) (MPyV)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

121-308 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P12905

Entry ID Method Resolution Chain Position Source

No variants for P12905

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P12905

No associated diseases with P12905

5 regional properties for P12905

Type Name Position InterPro Accession
domain DnaJ domain 11 - 67 IPR001623
domain T antigen, Ori-binding 286 - 402 IPR003133
domain Large T antigen, polyomavirus, C-terminal 412 - 767 IPR010932
domain Helicase, superfamily 3, DNA virus 544 - 704 IPR014015
domain Zinc finger, large T-antigen D1-type 411 - 505 IPR017910

Functions

Description
EC Number
Subcellular Localization
  • Host nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA replication origin binding Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
modulation by virus of host G1/S transition checkpoint Any viral process that modulates the frequency, rate or extent of the host cell G1/S transition checkpoint.
suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host JAK1 (Janus Kinase 1).
suppression by virus of host type I interferon-mediated signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDRVLSRADK ERLLELLKLP RQLWGDFGRM QQAYKQQSLL LHPDKGGSHA LMQELNSLWG
70 80 90 100 110 120
TFKTEVYNLR MNLGGTGFQN AERGTEESGH SPLHDDYWSF SYGSKYFTRE WNDFFRKWDP
130 140 150 160 170 180
SYQSPPKTAE SSEQPDLFCY EEPLLSPNPS PPTDTPAHPA GRRRNPCVAE PDDSISPDPP
190 200 210 220 230 240
RTPVSRKRPR PAGATGGGGG GVHANGGSVF GHPTGGTSTP AHPPPYHSQG GSESMGGSDS
250 260 270 280 290 300
SGFAEGSFRS DPRGESENES YSQSCSQSSF NATPPKKARE DPAPSDFPSS LTGYLSHAIY
310 320 330 340 350 360
SNKTFPAFLV YSTKEKCKQL YDTIGKFRPE FKCLVHYEEG GMLFFLTMTK HRVSAVKNYC
370 380 390 400 410 420
SKLCSVSFLM CKAVTKPMEC YQVVTAAPFQ LITENKPGLH QFEFTDEPEE QKAVDWIMVA
430 440 450 460 470 480
DFALENNLDD PLLIMGYYLD FAKEVPSCIK CSKEETRLQI HWKNHRKHAE NADLFLNCKA
490 500 510 520 530 540
QKTICQQAAD GVLASRRLKL VECTRSQLLK ERLQQSLLRL KELGSSDALL YLAGVAWYQC
550 560 570 580 590 600
LLEDFPQTLF KMLKLLTENV PKRRNILFRG PVNSGKTGLA AALISLLGGK SLNINCPADK
610 620 630 640 650 660
LAFELGVAQD QFVVCFEDVK GQIALNKQLQ PGMGVANLDN LRDYLDGSVK VNLEKKHSNK
670 680 690 700 710 720
RSQLFPPCVC TMNEYLLPQT VWARFHMVLD FTCKPHLAQA LEKCEFLQRE RIIQSGDTLA
730 740 750 760 770
LLLIWNFTSD VFDPDIQGLV KEVRDQFAAE CSYSLFCDIL CNVQEGDDPL KDICEYS