P12474

PR
Gene name
Protein name
Outer capsid protein VP4
Names
Hemagglutinin
Species
Rotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

527-610 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P12474

Entry ID Method Resolution Chain Position Source

No variants for P12474

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P12474

No associated diseases with P12474

3 regional properties for P12474

Type Name Position InterPro Accession
domain Haemagglutinin outer capsid protein VP4, concanavalin-like domain 65 - 224 IPR000416
domain Rotavirus VP4 helical domain 486 - 776 IPR035329
domain Rotavirus VP4, membrane interaction domain 250 - 474 IPR035330

Functions

Description
EC Number
Subcellular Localization
  • [Outer capsid protein VP4]: Virion
  • Host rough endoplasmic reticulum
  • Host cell membrane
  • Host cytoplasm, host cytoskeleton
  • Host endoplasmic reticulum-Golgi intermediate compartment
  • The outer layer contains 180 copies of VP4, grouped as 60 dimers
  • Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4
  • As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles
  • VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
host cell endoplasmic reticulum-Golgi intermediate compartment A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport.
host cell plasma membrane The plasma membrane surrounding a host cell.
host cell rough endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface.
host cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic host cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
viral outer capsid The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
permeabilization of host organelle membrane involved in viral entry into host cell Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm.
viral entry via permeabilization of inner membrane The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane.
virion attachment to host cell The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASLIYRQLL ANSYAVNLSD EIQSVGSGKN QRVTVNPGPF AQTGYAPVNW GPGEVNDSTV
70 80 90 100 110 120
VQPVLDGPYQ PAPFDLPVGN WMLLAPTRPG VVVEGTDNSG RWLSVILIEP GVASETRTYM
130 140 150 160 170 180
MFGSSKQVVV SNVSDTKWKF VEMVKTAVDG DYAEWGTLLS DTKLYGMMKY GRRLFIYEGE
190 200 210 220 230 240
TPNATTKGYF ITNYASAEVR PYSDFYIISR SQESACTEYI NNGLPPIQNT RNVVPVAISS
250 260 270 280 290 300
RSIKPREVQA NEDIVVSKTS LWKEMQYNRD IIIRFKFDNS IIKSGGLGYK WAEISFKAAN
310 320 330 340 350 360
YQYNYMRDGE EVTAHTTCSV NGVNDFSFNG GSLPTDFAIS RYEVIKENSY VYVDYWDDSQ
370 380 390 400 410 420
AFRNMVYVRS LAANLNDVMC SGGHYSFALP VGQWPVMKGG AVTLHTAGVT LSTQFTDFVS
430 440 450 460 470 480
LNSLRFRFRL AVEEPSFTIT RTRVSKLYGL PAANPNGGKE YYEVAGRFSF ISLVPSNDDY
490 500 510 520 530 540
QTPIMNSVTV RQDLERRLNE LREEFNNLSQ EIAVSQLIDL AMLPLDMFSM FSGIESTVNA
550 560 570 580 590 600
AKSMATNVMR KFKSSKLASS VSMLTDSLSD AASSIARSTS VRSIGSTASA WANISEQTQD
610 620 630 640 650 660
AVSEVATISS QVSQISGRLR LKEITTQTEG MNFDDISAAV LKAKIDRSIQ VDQNALPDVI
670 680 690 700 710 720
TEASEKFIRN RAYRVIDGDE AFEAGTDGRF FAYKVETLEE MPFNMEKFAD LVTNSPVISA
730 740 750 760 770
IIDFKTLKNL NDNYGITREQ AFNLLRSDPK VLRGFIDQNN PIIKNRIEQL IMQCRL