P12461

PR
Gene name
TMP1 (CDC21, TSA1, CAALFM_C205190WA, CaO19.11033, CaO19.3549)
Protein name
Thymidylate synthase
Names
TS, TSase
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C205190WA
EC number
2.1.1.45: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-78 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P12461

Entry ID Method Resolution Chain Position Source
AF-P12461-F1 Predicted AlphaFoldDB

No variants for P12461

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P12461

No associated diseases with P12461

2 regional properties for P12461

Type Name Position InterPro Accession
active_site Thymidylate synthase, active site 156 - 184 IPR020940
domain Thymidylate synthase/dCMP hydroxymethylase domain 10 - 315 IPR023451

Functions

Description
EC Number 2.1.1.45 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
thymidylate synthase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.

3 GO annotations of biological process

Name Definition
dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).
dTTP biosynthetic process The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVSPNTAEQ AYLDLCKRII DEGEHRPDRT GTGTKSLFAP PQLRFDLSND TFPLLTTKKV
70 80 90 100 110 120
FSKGIIHELL WFVAGSTDAK ILSEKGVKIW EGNGSREFLD KLGLTHRREG DLGPVYGFQW
130 140 150 160 170 180
RHFGAEYKDC DSDYTGQGFD QLQDVIKKLK TNPYDRRIIM SAWNPPDFAK MALPPCHVFC
190 200 210 220 230 240
QFYVNFPTSS PDPNNPKQAK TAKPKLSCLL YQRSCDMGLG VPFNIASYAL LTKMIAHVVD
250 260 270 280 290 300
MDCGEFIHTL GDAHVYLDHI DALKEQFERI PKQFPKLVIK EERKNEIKSI DDFKFEDFEI
310
VGYEPYPPIK MKMSV