P12293

PR
Gene name
moxF
Protein name
Methanol dehydrogenase [cytochrome c] subunit 1
Names
MDH large subunit alpha, MEDH
Species
Paracoccus denitrificans
KEGG Pathway
EC number
1.1.2.7: With a cytochrome as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P12293

Entry ID Method Resolution Chain Position Source
1LRW X-ray 250 A A/C 33-631 PDB
AF-P12293-F1 Predicted AlphaFoldDB

No variants for P12293

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P12293

No associated diseases with P12293

1 regional properties for P12293

Type Name Position InterPro Accession
domain Aspartate/glutamate/uridylate kinase 39 - 218 IPR001048

Functions

Description
EC Number 1.1.2.7 With a cytochrome as acceptor
Subcellular Localization
  • Periplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.

2 GO annotations of molecular function

Name Definition
alcohol dehydrogenase (cytochrome c(L)) activity Catalysis of the reaction: 2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H+.
calcium ion binding Binding to a calcium ion (Ca2+).

1 GO annotations of biological process

Name Definition
methanol metabolic process The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNRNTPKARG ASSLAMAVAM GLAVLTTAPA TANDQLVELA KDPANWVMTG RDYNAQNYSE
70 80 90 100 110 120
MTDINKENVK QLRPAWSFST GVLHGHEGTP LVVGDRMFIH TPFPNTTFAL DLNEPGKILW
130 140 150 160 170 180
QNKPKQNPTA RTVACCDVVN RGLAYWPGDD QVKPLIFRTQ LDGHIVAMDA ETGETRWIME
190 200 210 220 230 240
NSDIKVGSTL TIAPYVIKDL VLVGSSGAEL GVRGYVTAYD VKSGEMRWRA FATGPDEELL
250 260 270 280 290 300
LAEDFNAPNP HYGQKNLGLE TWEGDAWKIG GGTNWGWYAY DPEVDLFYYG SGNPAPWNET
310 320 330 340 350 360
MRPGDNKWTM AIWGREATTG EAKFAYQKTP HDEWDYAGVN VMMLSEQEDK QGQMRKLLTH
370 380 390 400 410 420
PDRNGIVYTL DRTNGDLISA DKMDDTVNWV KEVQLDTGLP VRDPEFGTRM DHKARDICPS
430 440 450 460 470 480
AMGYHNQGHD SYDPERKVFM LGINHICMDW EPFMLPYRAG QFFVGATLTM YPGPKATAER
490 500 510 520 530 540
AGAGQIKAYD AISGEMKWEK MERFSVWGGT MATAGGLTFY VTLDGFIKAR DSDTGDLLWK
550 560 570 580 590 600
FKLPSGVIGH PMTYKHDGRQ YVAIMYGVGG WPGVGLVFDL ADPTAGLGSV GAFKRLQEFT
610 620 630
QMGGGVMVFS LDGESPYSDP NVGEYAPGEP T