P11862
Gene name |
Gas2 (Gas-2) |
Protein name |
Growth arrest-specific protein 2 |
Names |
GAS-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14453 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P11862
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1V5R | NMR | - | A | 201-284 | PDB |
| AF-P11862-F1 | Predicted | AlphaFoldDB |
18 variants for P11862
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388872982 | 2 | M>I | No | EVA | |
| rs3388872997 | 9 | K>T | No | EVA | |
| rs3388914276 | 40 | D>N | No | EVA | |
| rs3388914089 | 80 | K>I | No | EVA | |
| rs3388908395 | 108 | F>L | No | EVA | |
| rs3397495161 | 141 | K>M | No | EVA | |
| rs3397136635 | 143 | P>H | No | EVA | |
| rs3397664464 | 143 | P>T | No | EVA | |
| rs3397922589 | 144 | R>* | No | EVA | |
| rs250627615 | 179 | T>A | No | EVA | |
| rs3388913771 | 189 | P>L | No | EVA | |
| rs3388873010 | 196 | K>* | No | EVA | |
| rs3388914247 | 220 | T>I | No | EVA | |
| rs3388872943 | 235 | G>R | No | EVA | |
| rs3388916329 | 269 | P>L | No | EVA | |
| rs3388916917 | 271 | R>S | No | EVA | |
| rs3388905884 | 287 | S>C | No | EVA | |
| rs3388872996 | 308 | K>R | No | EVA |
No associated diseases with P11862
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin filament | A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| cytoskeletal anchor activity | The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way. |
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| actin crosslink formation | The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes. |
| antral ovarian follicle growth | Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity. |
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| basement membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. |
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| initiation of primordial ovarian follicle growth | Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle). |
| ovulation | The release of a mature ovum/oocyte from an ovary. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| regulation of Notch signaling pathway | Any process that modulates the frequency, rate or extent of the Notch signaling pathway. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O43903 | GAS2 | Growth arrest-specific protein 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMCTALSPKV | RSGPGLSDMH | QYSQWLASRH | EANLLPMKED | LALWLTNLLG | KEITAETFME |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KLDNGALLCQ | LAATVQEKFK | ESMDANKPAK | TLPLKKIPCK | ASAPSGSFFA | RDNTANFLSW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CRDLGVDETC | LFESEGLVLH | KQPREVCLCL | LELGRIAARY | GVEPPGLIKL | EKEIEQEETL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SAPSPSPSPS | SKSSGKKSTG | NLLDDAVKRI | SEDPPCKCPT | KFCVERLSQG | RYRVGEKILF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IRMLHNKHVM | VRVGGGWETF | AGYLLKHDPC | RMLQISRVDG | KTSPVQSKSP | TLKDMNPDNY |
| 310 | |||||
| LVVSATYKAK | KEIK |