P11512

PR
Gene name
rpo1N
Protein name
DNA-directed RNA polymerase subunit Rpo1N
Names
DNA-directed RNA polymerase subunit A, DNA-directed RNA polymerase subunit A', Rpo1'
Species
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
KEGG Pathway
sai:Saci_0692
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

256-351 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P11512

Entry ID Method Resolution Chain Position Source
7OK0 EM 290 A A 1-880 PDB
7OQ4 EM 327 A A 1-880 PDB
7OQY EM 261 A A 1-880 PDB
AF-P11512-F1 Predicted AlphaFoldDB

No variants for P11512

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P11512

No associated diseases with P11512

6 regional properties for P11512

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 315 - 482 IPR000722
domain RNA polymerase, N-terminal 205 - 510 IPR006592
domain RNA polymerase Rpb1, domain 3 485 - 651 IPR007066
domain RNA polymerase Rpb1, domain 1 4 - 313 IPR007080
domain RNA polymerase Rpb1, domain 5 789 - 854 IPR007081
domain RNA polymerase Rpb1, domain 4 679 - 782 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEKIIRGVK FGVLSPNEIR QMSVTAIITS EVYDEDGTPI EGGVMDPKLG VIEPGQKCPV
70 80 90 100 110 120
CGNTLAGCPG HFGHIELIKP VIHIGYVKHI YDFLRSTCWR CGRIKIKEQD LERYKRIYNA
130 140 150 160 170 180
IKLRWPSAAR RLVEYIKKIS IKNLECPHCG EKQFKIKLEK PYNFNEERNG SIVKLSPSEI
190 200 210 220 230 240
RDRLERIPDS DVELLGYDPK SSRPEWMILT VLPVPPITIR PSITIESGIR AEDDLTHKLV
250 260 270 280 290 300
DIIRLNERLK ESIEAGAPQL IIEDLWDLLQ YHVATYFDNE IPGLPPAKHR SGRPLRTLAQ
310 320 330 340 350 360
RLKGKEGRFR GNLSGKRVDF SARTVISPDP NLSIDEVGIP YTIARMLTVP ERVTNINIER
370 380 390 400 410 420
IRQYIINGPD KWPGANYVIK PDGRRIDLRY VKDRKELASS ITAGYVVERH LVDGDVVLFN
430 440 450 460 470 480
RQPSLHRISM MAHKVRVLPG RTFRLNLLDC PPYNADFDGD EMNLHVPQSE EAIAEARELM
490 500 510 520 530 540
LVHKNIITPR YGGPIIGGGQ DYISGAYLLS VKTTLLTVEE VATILGVTDF VGELGEPAIL
550 560 570 580 590 600
APKPYYTGKQ VISLFLPKDF NFHGPANISK GPRACKDEIC PHDSFIVIKN GLLLEGVFDK
610 620 630 640 650 660
KAIGNQQPES MLHWSIREYG TEYGKWLMDN VFKMFIRFLE MRGFTMTLED ITIPDEAQNE
670 680 690 700 710 720
ITTKIKEGYS QVDEYIRKFN EGQLEPIPGR TIEESLESYI LDTLDKLRKV AGEIATKYLD
730 740 750 760 770 780
PFNNVYIMAI TGARGSELNI TQMTALLGQQ SVRGERIRRG YRERTLSLFK YGDIAPEARG
790 800 810 820 830 840
FVKNSFMRGL SPYEMFFHAA GGREGLVDTA VKTSQSGYMQ RRLINALSDL RIEYDGTVRS
850 860 870
LYGDIVQVVY GDDAVHPMYS AHSKSVNVNR VIERVIGWKR