P11434

PR
Gene name
epb41
Protein name
Protein 4.1
Names
Band 4.1, Erythrocyte membrane protein band 4.1
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:397741
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-215 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P11434

Entry ID Method Resolution Chain Position Source
AF-P11434-F1 Predicted AlphaFoldDB

No variants for P11434

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P11434

No associated diseases with P11434

11 regional properties for P11434

Type Name Position InterPro Accession
domain FERM domain 193 - 474 IPR000299
domain SAB domain 605 - 653 IPR007477
domain Band 4.1, C-terminal 692 - 799 IPR008379
domain FERM adjacent 481 - 527 IPR014847
domain FERM, N-terminal 197 - 258 IPR018979
domain FERM, C-terminal PH-like domain 388 - 478 IPR018980
conserved_site FERM conserved site 247 - 275 IPR019747-1
conserved_site FERM conserved site 354 - 383 IPR019747-2
domain FERM central domain 277 - 384 IPR019748
domain Band 4.1 domain 189 - 384 IPR019749
domain Band 4.1 protein, FERM domain, F1 sub-domain 193 - 275 IPR021187

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cell cortex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

4 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
positive regulation of protein localization to cell cortex Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTEKGLLAE AESPPQDQKQ EGEEEVESCT TQPVVGSGDK DPETEQSQES PSTTSPSTRK
70 80 90 100 110 120
SKDRHSQGKG LSRLFSSFLK RPKSQVSSDE KEVELLGEKG QDQKDVDEGL GEQLEDDVFL
130 140 150 160 170 180
KAPIAAPEPE LRTDPSLDLH SLSSAETQPA QEEQKEDQDP EADCEDVEGK EPIKKPEGES
190 200 210 220 230 240
KASHKVVRRS PNMRCKVTLL DDTVYECDLE KHAKGQDIFK KVCSHLNIVE EDYFGLAIWE
250 260 270 280 290 300
SPTCKVWLDP LKDIRKQVHG GPCEFTSNVK FYPPDPAQLS EDITRYYLCL QLRKDIFSGR
310 320 330 340 350 360
LPCSFATLAL LGSYTVQSEV GDYEEDLHGV DYVSEFKLSP NQTKDLEEKV GELHKSYRSM
370 380 390 400 410 420
TPAQADLEFL ENAKKLTMYG VDIHQAKDLE GVDIKLGVCS GGLMVFKDNL RINRFPWPKV
430 440 450 460 470 480
LKISYKRSSF FIKIRPGEQE QYESTIGFKL PSYKAAKKLW KVCVEHHTFF RLTSTESIPK
490 500 510 520 530 540
HRFLSLGSTF RYSGRTQAQT RHASALIDRP APHFVRTGSK RASRSLDGAA VATPEASRTH
550 560 570 580 590 600
RPVSAPVFPP EFPAVQRKTP GPRVEEMPKK TEEKPKEGMP NQRESPKDVK ATQQDSPSPT
610 620 630 640 650 660
VNGDKVKDLE KTQDEIIRHH ASIRELKKSF MESVPAPRPS EWDKRLSTHS PFRTLSFNGQ
670 680 690 700 710 720
VQTGTDGPPL VKTQTVTISN ATNGEKGEIP TKEVPLVHTE TKTITYEAAR SDDVNTDQEP
730 740 750 760 770 780
GILLTAHTIT SETTSSTTTT QITKTVKGGI SETLIEKRIV ITGDGDLDHD QVLVQAIKEA
790 800
KEQHPDMSVT KGVVHQETEI A