P11356

PR
Gene name
POX2
Protein name
Acyl-coenzyme A oxidase 2
Names
Acyl-CoA oxidase 2, PXP-2
Species
Candida tropicalis (Yeast)
KEGG Pathway
EC number
1.3.3.6: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-135 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P11356

Entry ID Method Resolution Chain Position Source
AF-P11356-F1 Predicted AlphaFoldDB

No variants for P11356

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P11356

No associated diseases with P11356

3 regional properties for P11356

Type Name Position InterPro Accession
domain Acyl-CoA oxidase, C-terminal 553 - 702 IPR002655
domain Acyl-CoA oxidase/dehydrogenase, middle domain 176 - 285 IPR006091
domain Acyl-coenzyme A oxidase, N-terminal 53 - 164 IPR029320

Functions

Description
EC Number 1.3.3.6 With oxygen as acceptor
Subcellular Localization
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

2 GO annotations of molecular function

Name Definition
acyl-CoA oxidase activity Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

1 GO annotations of biological process

Name Definition
fatty acid beta-oxidation using acyl-CoA oxidase A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAMLSQPNDG HDHPEKKDPD TTPKQVAGVI SSQDPPHPAK DVAEERARTD WDLKEMHEFL
70 80 90 100 110 120
EGDEAKSEQI LRLYQSIERD PILQTRPEQF DYTQKQEREL VANRINQMTK FLETEPYGKF
130 140 150 160 170 180
RRRLQLMTVI DPSLGIRMLV NIGLFLNCVR GNGTQKQFDF WSNKKEAGIV KQLYGCFGMT
190 200 210 220 230 240
ELGHGSNVAG CETTATFDEK TDEFIIDTPH IGATKWWIGG AAHSATHTVC YARLIVKDVD
250 260 270 280 290 300
YGVKTFIVPL RDSRHSLLPG IAIGDIGAKM GRQGVDNGWI QFTEVRVPRF FMLQRWCKVD
310 320 330 340 350 360
RQGNVTLPPL EQLSYISLLE GRVGMATDSY RIGARYTTIA LRYAVGRRQF SKKAGEPETK
370 380 390 400 410 420
LIDYTLHQRR LLPYLALTYA AAVGTDRLER QHEELLANLD IALAKKDKLL LKNTITGTKS
430 440 450 460 470 480
MFVDSGSLKS TLTWLAADLI NETRQACGGH GYSSYNGFGK TYDDWVVQCT WEGDNNVLAM
490 500 510 520 530 540
SAGKTIIKTV QQVLNGKELK DSTLEFLNAA PELSKAKKAV IRIRDHVDDV DRVLKAIAGL
550 560 570 580 590 600
ISKFSKDLIP ISYQSWDSIG AQRVILSKLR CHYYLLETFN ERLNDKIKAK SPARPHLENI
610 620 630 640 650 660
IKLYYVTNIL GPFIDEFLRF GVISPQVAKY ITYEYPQKLC ANIRPYVIGL TDSFQQPDNF
670 680 690 700 710 720
INSLIGKYDG NIYTNYLESV KDVNDPSNYK APYSEALEAM LNRSALENRE RSERGKAAAD
ILSK