P10830

PR
Gene name
PRKCE
Protein name
Protein kinase C epsilon type
Names
nPKC-epsilon
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009103
EC number
2.7.11.13: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

263-428 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

548-571 (Activation loop from InterPro)

Target domain

411-731 (Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P10830

Entry ID Method Resolution Chain Position Source
AF-P10830-F1 Predicted AlphaFoldDB

No variants for P10830

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P10830

No associated diseases with P10830

13 regional properties for P10830

Type Name Position InterPro Accession
domain C2 domain 1 - 117 IPR000008
domain Protein kinase domain 407 - 667 IPR000719
domain AGC-kinase, C-terminal 668 - 736 IPR000961
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 169 - 220 IPR002219-1
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 242 - 294 IPR002219-2
active_site Serine/threonine-protein kinase, active site 527 - 539 IPR008271
binding_site Protein kinase, ATP binding site 413 - 436 IPR017441
domain Protein kinase, C-terminal 691 - 729 IPR017892
domain Diacylglycerol/phorbol-ester binding 167 - 181 IPR020454-1
domain Diacylglycerol/phorbol-ester binding 183 - 192 IPR020454-2
domain Diacylglycerol/phorbol-ester binding 197 - 208 IPR020454-3
domain Diacylglycerol/phorbol-ester binding 281 - 293 IPR020454-4
domain Novel protein kinase C epsilon, catalytic domain 411 - 731 IPR034669

Functions

Description
EC Number 2.7.11.13 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytoskeleton
  • Cell membrane
  • Cytoplasm, perinuclear region
  • Nucleus
  • Translocated to plasma membrane in epithelial cells stimulated by HGF (By similarity)
  • Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity)
  • In passaging cells, translocated to the cell periphery (By similarity)
  • Translocated to the nucleus in PMA-treated cells (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name Definition
actin monomer binding Binding to monomeric actin, also known as G-actin.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium-dependent protein kinase C activity Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
calcium-independent protein kinase C activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.
metal ion binding Binding to a metal ion.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

12 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
lipopolysaccharide-mediated signaling pathway The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
positive regulation of actin filament polymerization Any process that activates or increases the frequency, rate or extent of actin polymerization.
positive regulation of cytokinesis Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
positive regulation of epithelial cell migration Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
positive regulation of fibroblast migration Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
positive regulation of wound healing Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
protein phosphorylation The process of introducing a phosphate group on to a protein.
TRAM-dependent toll-like receptor 4 signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT
70 80 90 100 110 120
NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE
130 140 150 160 170 180
PEGKVYVIID LSGSSGEAPK DNEERVFRER MRPRKRQGAV RRRVHQVNGH KFMATYLRQP
190 200 210 220 230 240
TYCSHCRDFI WGVIGKQGYQ CQVCTCVVHK RCHELIITKV AGLKKQETPD EVGSQRFSVN
250 260 270 280 290 300
MPHKFGIHNY KVPTFCDHCG SLLWGLLRQG LQCKVCKMNV HRRCETNVAP NCGVDARGIA
310 320 330 340 350 360
KVLADLGVTP DKITNSGQRR KKLIGGAESP QPTSGSSPSE EDRSKSAPTS PCDQELKELE
370 380 390 400 410 420
NNIRKALSFD NRGEEHRAAS STDGQLGSPE NGEVRQGQAK RLGLDEFNFI KVLGKGSFGK
430 440 450 460 470 480
VMLAELKGKD EVYAVKVLKK DVILQDDDVD CTMTEKRILA LARKHPYLTQ LYCCFQTKDR
490 500 510 520 530 540
LFFVMEYVNG GDLMFQIQRS RKFDEPRSRF YAAEVTSALM FLHQHGVIYR DLKLDNILLD
550 560 570 580 590 600
AEGHCKLADF GMCKEGILNG VTTTTFCGTP DYIAPEILQE LEYGPSVDWW ALGVLMYEMM
610 620 630 640 650 660
AGQPPFEADN EDDLFESILH DDVLYPVWLS KEAVSILKAF MTKNPHKRLG CVAAQNGEDA
670 680 690 700 710 720
IKQHPFFKEI DWVLLEQKKI KPPFKPRIKT KRDVNNFDQD FTREEPVLTL VDEAIVKQIN
730
QEEFKGFSYF GEDLMP