P10726

PR
Gene name
sigD (flaB, BSU16470)
Protein name
RNA polymerase sigma-D factor
Names
Sigma-28
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU16470
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

73-254 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P10726

Entry ID Method Resolution Chain Position Source
AF-P10726-F1 Predicted AlphaFoldDB

No variants for P10726

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P10726

No associated diseases with P10726

5 regional properties for P10726

Type Name Position InterPro Accession
domain RNA polymerase sigma-70 9 - 254 IPR000943
domain RNA polymerase sigma-70 region 3 106 - 184 IPR007624
domain RNA polymerase sigma-70 region 2 27 - 99 IPR007627
domain RNA polymerase sigma-70 region 4 200 - 246 IPR007630
domain RNA polymerase sigma-70 like domain 25 - 248 IPR014284

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

3 GO annotations of biological process

Name Definition
bacterial-type flagellum-dependent swarming motility Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQSLNYEDQV LWTRWKEWKD PKAGDDLMRR YMPLVTYHVG RISVGLPKSV HKDDLMSLGM
70 80 90 100 110 120
LGLYDALEKF DPSRDLKFDT YASFRIRGAI IDGLRKEDWL PRTSREKTKK VEAAIEKLEQ
130 140 150 160 170 180
RYLRNVSPAE IAEELGMTVQ DVVSTMNEGF FANLLSIDEK LHDQDDGENI QVMIRDDKNV
190 200 210 220 230 240
PPEEKIMKDE LIAQLAEKIH ELSEKEQLVV SLFYKEELTL TEIGQVLNLS TSRISQIHSK
250
ALFKLKNLLE KVIQ