P10674
Gene name |
Fas1 (CG6588) |
Protein name |
Fasciclin-1 |
Names |
Fasciclin I, FAS I, FCN |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG6588 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P10674
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1O70 | X-ray | 260 A | A | 314-628 | PDB |
| AF-P10674-F1 | Predicted | AlphaFoldDB |
No variants for P10674
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P10674 | |||||
No associated diseases with P10674
4 regional properties for P10674
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FAS1 domain | 20 - 147 | IPR000782-1 |
| domain | FAS1 domain | 166 - 313 | IPR000782-2 |
| domain | FAS1 domain | 317 - 466 | IPR000782-3 |
| domain | FAS1 domain | 467 - 619 | IPR000782-4 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchored component of membrane | The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
| extracellular matrix | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cell adhesion molecule binding | Binding to a cell adhesion molecule. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules | The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| extracellular matrix organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| neuron recognition | The process in which a neuronal cell in a multicellular organism interprets its surroundings. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLNAAALLLA | LLCAANAAAA | ADLADKLRDD | SELSQFYSLL | ESNQIANSTL | SLRSCTIFVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TNEAFQRYKS | KTAHVLYHIT | TEAYTQKRLP | NTVSSDMAGN | PPLYITKNSN | GDIFVNNARI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IPSLSVETNS | DGKRQIMHII | DEVLEPLTVK | AGHSDTPNNP | NALKFLKNAE | EFNVDNIGVR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TYRSQVTMAK | KESVYDAAGQ | HTFLVPVDEG | FKLSARSSLV | DGKVIDGHVI | PNTVIFTAAA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QHDDPKASAA | FEDLLKVTVS | FFKQKNGKMY | VKSNTIVGDA | KHRVGVVLAE | IVKANIPVSN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GVVHLIHRPL | MIIDTTVTQF | LQSFKENAEN | GALRKFYEVI | MDNGGAVLDD | INSLTEVTIL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| APSNEAWNSS | NINNVLRDRN | KMRQILNMHI | IKDRLNVDKI | RQKNANLIAQ | VPTVNNNTFL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YFNVRGEGSD | TVITVEGGGV | NATVIQADVA | QTNGYVHIID | HVLGVPYTTV | LGKLESDPMM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SDTYKMGKFS | HFNDQLNNTQ | RRFTYFVPRD | KGWQKTELDY | PSAHKKLFMA | DFSYHSKSIL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ERHLAISDKE | YTMKDLVKFS | QESGSVILPT | FRDSLSIRVE | EEAGRYVIIW | NYKKINVYRP |
| 610 | 620 | 630 | 640 | 650 | |
| DVECTNGIIH | VIDYPLLEEK | DVVVAGGSYL | PESSICIILA | NLIMITVAKF | LN |