P10650

PR
Gene name
MOS
Protein name
Proto-oncogene serine/threonine-protein kinase mos
Names
Oocyte maturation factor mos, Proto-oncogene c-Mos
Species
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

218-244 (Activation loop from InterPro)

Target domain

60-341 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P10650

Entry ID Method Resolution Chain Position Source
AF-P10650-F1 Predicted AlphaFoldDB

No variants for P10650

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P10650

No associated diseases with P10650

2 regional properties for P10650

Type Name Position InterPro Accession
domain Thioredoxin domain 13 - 158 IPR013766
conserved_site Thioredoxin, conserved site 51 - 69 IPR017937

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

7 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
establishment of meiotic spindle orientation Any process that set the alignment of meiotic spindle relative to other cellular structures.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
meiotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
negative regulation of metaphase/anaphase transition of meiotic cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSPLALRPY LPSEFSPSVD ARPCSSPSEL PAKLLLGATP PRAPRLPRRL AWCSIDWEQV
70 80 90 100 110 120
CLLQRLGAGG FGSVYKATYH GVPVAIKQVN KCTKNRLASR RSFWAELNVA RLRHDNIVRV
130 140 150 160 170 180
VAASTRTPAG SNSLGTIIME FGGNVTLHQV IYGAASHPEG DAGEPHCSTG GPLTLGKCLK
190 200 210 220 230 240
YSLDVVNGLL FLHSQSIVHL DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPLYPLG
250 260 270 280 290 300
GTYTHRAPEL LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS
310 320 330 340
AAVFQDSLPG QRLGDVIRRC WRPSAAQRPS ARPLLVDLTS LKAEFG