Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P10582

Entry ID Method Resolution Chain Position Source
AF-P10582-F1 Predicted AlphaFoldDB

No variants for P10582

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P10582

No associated diseases with P10582

3 regional properties for P10582

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family B, mitochondria/virus 302 - 395 IPR004868-1
domain DNA-directed DNA polymerase, family B, mitochondria/virus 401 - 723 IPR004868-2
conserved_site DNA-directed DNA polymerase, family B, conserved site 727 - 735 IPR017964

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQPARRHTKK KNMNYMRYES LTREQFERFL KDVHKCYRGE PRYVIPYEGH LIAVQDFEEP
70 80 90 100 110 120
YPKAGAVTML ASAFMELLIN RVYPSIQGSA KFTLQYRLNI DGNPINITLS KAIKLTYADG
130 140 150 160 170 180
TRIANEFILK EIINVLNKYA ENYQSCDVEA ISVRAYSEGS IDLNQASIPT KDESLNYLKG
190 200 210 220 230 240
ALIKYSDINN LEIPKMGRRS KRRYQSYIPV DKTEMKNKTL FFVADLETLL LKRRDTDVDK
250 260 270 280 290 300
THVPYAGGYM MVDMEKWVNA DHITTFYAHD YSKVCQDFHD MSEKMLTEMI NRIVKDVQRR
310 320 330 340 350 360
GSSMVVYFHN LSQFDGIMIL SFLTKSYKNC HIEPIMRNDC IYSIKLYKVS KNGDKRLVLT
370 380 390 400 410 420
FMDSYLLLKV KLADLADSFC PELGGKGSFD HQNVTVDKLP SIREDSLTYL KQDILITAAV
430 440 450 460 470 480
MQRAKAIIWE EYGIDILKVL TISALALKIF RRVYYKDDDD NWIYIPDDNE AQFIREGYYG
490 500 510 520 530 540
GHTDVYKPYG ENLYYYDVNS LYPSSMLDDM PIGKTRWVSD LGSKKSKIVL NDMFGFIRAF
550 560 570 580 590 600
IICPKHIKKP LLPYKKDDGT IIFPTGRFLG VYFSEELKYA VSLGYKVYPI CGYIFDRKES
610 620 630 640 650 660
PFKRFVYDIY SKRLDAKAKG EKALDFIYKI TMNSLYGRFG ISPESTTTQI VSTEESRKLA
670 680 690 700 710 720
LYNDGFVQSY ELSSDKCLVT CKNVRSLDLL KLSSDRPTYA AVQISAAVTG YARIRMHPFI
730 740 750 760 770 780
SRDDCYYTDT DSVVVERELP EEEVSPTALG KFKHEHFVEY GIFLAPKSYM LKASSVDQPI
790 800 810 820 830 840
IKFKGAGKDE ADEEWFINQL ADPRAKKVIS YVRKFSRNFR ELLVQEKMCK YTMGLESKKR
850 860 870 880 890 900
EYVFDKNGVW VDTKPCHIGD FDVKSINPTS YWIIMNLLEE NEDLRNEFSN SEIMIANWEI
910 920
KADAAKKRKA SKLRGKPLRG GDTPSHIEE