Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P10569
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P10569-F1 | Predicted | AlphaFoldDB |
No variants for P10569
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P10569 | |||||
No associated diseases with P10569
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell leading edge | The area of a motile cell closest to the direction of movement. |
| myosin complex | A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasma membrane bounded cell projection | A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cytoskeletal motor activity | Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| cellular component assembly | The aggregation, arrangement and bonding together of a cellular component. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| locomotion | Self-propelled movement of a cell or organism from one location to another. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAYTSKHGVD | DMVMLTSISN | DAINDNLKKR | FAADLIYTYI | GHVLISVNPY | KQINNLYTER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TLKDYRGKYR | YELPPHVYAL | ADDMYRTMLS | ESEDQCVIIS | GESGAGKTEA | SKKIMQYIAA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VSGATGDVMR | VKDVILEAFG | NAKTIRNNNS | SRFGKYMEIQ | FDLKGDPVGG | RISNYLLEKS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RVVYQTNGER | NFHIFYQLLA | ARARRPEAKF | GLQTPDYYFY | LNQGKTYTVD | GMDDNQEFQD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TWNAMKVIGF | TAEEQHEIFR | LVTAILYLGN | VQFVDDGKGG | STIADSRPVA | VETALLYRTI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TTGEQGRGRS | SVYSCPQDPL | GAIYSRDALS | KALYSRMFDY | IIQRVNDAMY | IDDPEALTTG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ILDIYGFEIF | GKNGFEQLCI | NFVNEKLQQI | FIQLTLKAEQ | EEYGAEGIQW | ENIDYFNNKI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CCDLIEEKRP | PGLMTILDDV | CNFPKGTDDK | FREKLLGAFP | THAHLAATSQ | PDEFVIKHYA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GDVVYNVDGF | CDKNKDLLFK | DLIGLAECTS | STFFAGLFPE | AKEVATSKKK | PTTAGFKIKE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SINILVATLS | KCTPHYIRCI | KPNEKKAANA | FNNSLVLHQV | KYLGLLENVR | IRRAGYAYRQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SYDKFFYRYR | VVCPKTWSGW | NGDMVSGAEA | ILNHVGMSLG | KEYQKGKTKI | FIRQPESVFS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LEELRDRTVF | SYANKIQRFL | RKTAMRKYYY | EVKKGGNDAL | VNKKERRRLS | LERPFKTDYI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NYRQNFKLKD | CIGDKGTEKV | LFADLCNNLD | KSFWGSKVER | RIMVLTSNAM | FLVAIDPNKD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KIEKKVKPFL | YVLKRRIDFN | KIGSITLSPL | QDNFMLISVN | GEHSNLLECR | RKTELIGVLL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KHNPSVRIQF | ADTFNVTLKG | GKTCVVKFIR | DPQGGDGKVK | GTKVSVAPGL | PPSSAPNIQA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PQETSGGASF | TVAEQSYKDQ | ILGAKGGGGG | GGRGRGGPSP | SGAVSPRPSP | GGGGGGPSPF |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GGRPSPSGPP | AAASAPGPEQ | ARALYDFAAE | NPDELTFNEG | AVVTVINKSN | PDWWEGELNG |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| QRGVFPASYV | ELIPRAAAPA | PGPSGGPRPA | PPGGKSGRAA | PMGGPGPMRG | RGGPAPGGPG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RGGAPPPGAG | RAGPPGGRGM | PAPGGAAPRG | RGAPPPGAGG | PPGGGRGGAP | PPGGMRGRGG |
| 1150 | 1160 | ||||
| PGPAPPGGMA | RGGMMPPRGR | AGPPPPGM |