P10477

PR
Gene name
celE
Protein name
Cellulase/esterase CelE
Names
CtCel5C-CE2
Species
Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)
KEGG Pathway
cth:Cthe_0797
EC number
3.1.1.72: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

449-520 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P10477

Entry ID Method Resolution Chain Position Source
2WAB X-ray 190 A A 485-814 PDB
2WAO X-ray 180 A A 485-814 PDB
4IM4 X-ray 242 A A/B/C/D/E/F 51-386 PDB
AF-P10477-F1 Predicted AlphaFoldDB

No variants for P10477

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P10477

No associated diseases with P10477

7 regional properties for P10477

Type Name Position InterPro Accession
domain Glycoside hydrolase, family 5 78 - 354 IPR001547
repeat Dockerin type I repeat 413 - 471 IPR002105
domain SGNH hydrolase-type esterase domain 608 - 799 IPR013830
domain Dockerin domain 409 - 479 IPR016134
conserved_site Glycoside hydrolase, family 5, conserved site 186 - 195 IPR018087
domain CtCE2-like domain 605 - 809 IPR037461
domain Carbohydrate esterase 2, N-terminal 494 - 599 IPR040794

Functions

Description
EC Number 3.1.1.72 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

4 GO annotations of molecular function

Name Definition
acetylxylan esterase activity Catalysis of the deacetylation of xylans and xylo-oligosaccharides.
cellulase activity Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
cellulose binding Binding to cellulose.
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
cellulose catabolic process The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
glucomannan catabolic process The chemical reactions and pathways resulting in the breakdown of a glucomannan.
xylan catabolic process The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKIVSLVCV LVMLVSILGS FSVVAASPVK GFQVSGTKLL DASGNELVMR GMRDISAIDL
70 80 90 100 110 120
VKEIKIGWNL GNTLDAPTET AWGNPRTTKA MIEKVREMGF NAVRVPVTWD THIGPAPDYK
130 140 150 160 170 180
IDEAWLNRVE EVVNYVLDCG MYAIINVHHD NTWIIPTYAN EQRSKEKLVK VWEQIATRFK
190 200 210 220 230 240
DYDDHLLFET MNEPREVGSP MEWMGGTYEN RDVINRFNLA VVNTIRASGG NNDKRFILVP
250 260 270 280 290 300
TNAATGLDVA LNDLVIPNND SRVIVSIHAY SPYFFAMDVN GTSYWGSDYD KASLTSELDA
310 320 330 340 350 360
IYNRFVKNGR AVIIGEFGTI DKNNLSSRVA HAEHYAREAV SRGIAVFWWD NGYYNPGDAE
370 380 390 400 410 420
TYALLNRKTL SWYYPEIVQA LMRGAGVEPL VSPTPTPTLM PTPSPTVTAN ILYGDVNGDG
430 440 450 460 470 480
KINSTDCTML KRYILRGIEE FPSPSGIIAA DVNADLKINS TDLVLMKKYL LRSIDKFPAE
490 500 510 520 530 540
DSQTPDEDNP GILYNGRFDF SDPNGPKCAW SGSNVELNFY GTEASVTIKS GGENWFQAIV
550 560 570 580 590 600
DGNPLPPFSV NATTSTVKLV SGLAEGAHHL VLWKRTEASL GEVQFLGFDF GSGKLLAAPK
610 620 630 640 650 660
PLERKIEFIG DSITCAYGNE GTSKEQSFTP KNENSYMSYA AITARNLNAS ANMIAWSGIG
670 680 690 700 710 720
LTMNYGGAPG PLIMDRYPYT LPYSGVRWDF SKYVPQVVVI NLGTNDFSTS FADKTKFVTA
730 740 750 760 770 780
YKNLISEVRR NYPDAHIFCC VGPMLWGTGL DLCRSYVTEV VNDCNRSGDL KVYFVEFPQQ
790 800 810
DGSTGYGEDW HPSIATHQLM AERLTAEIKN KLGW