P10398
PR
Gene name |
ARAF (ARAF1, PKS, PKS2) |
Protein name |
Serine/threonine-protein kinase A-Raf |
Names |
Proto-oncogene A-Raf, Proto-oncogene A-Raf-1, Proto-oncogene Pks |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:369 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
(Annotation based on sequence homology with P04049)
Raf proteins are Ras-regulated serine/threonine protein kinases that control the activation of the ERK/MARK cascade, and consists of three isoforms, A-Raf, B-Raf, and Raf-1 (C-Raf). When the catalytic domain of Raf-1 is expressed alone, it exhibits a constitutive activity. Raf-1 is regulated by an N-terminal autoinhibitory domain including Ras binding domain (RBD) and cysteine-rich domain (CRD). The autoinhibitory region blocks the catalytic kinase domain and the autoinhibition is interrupted by the interaction with active PAK1 or Src.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
446-471 (Activation loop from InterPro)
Target domain |
310-570 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
3 structures for P10398
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1WXM | NMR | - | A | 19-91 | PDB |
| 2MSE | NMR | - | D | 19-91 | PDB |
| AF-P10398-F1 | Predicted | AlphaFoldDB |
301 variants for P10398
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
RCV000421117 rs1057519876 RCV000438348 RCV000428557 COSM1742787 CA16602806 |
214 | S>A | biliary_tract Lung adenocarcinoma Papillary renal cell carcinoma, sporadic Malignant melanoma of skin [Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar Ensembl dbSNP |
|
rs1057519786 RCV000430187 RCV000427514 RCV000419218 CA16602595 RCV000436910 |
214 | S>C | Variant assessed as Somatic; impact. Non-small cell lung carcinoma Lung adenocarcinoma Papillary renal cell carcinoma, sporadic Malignant melanoma of skin [NCI-TCGA, ClinVar] | Yes |
ClinGen ClinVar Ensembl NCI-TCGA dbSNP |
|
rs1057519786 RCV000435898 RCV000429142 COSM612884 RCV000417875 CA16602805 |
214 | S>F | lung Variant assessed as Somatic; impact. Lung adenocarcinoma Papillary renal cell carcinoma, sporadic Malignant melanoma of skin [Cosmic, NCI-TCGA, ClinVar] | Yes |
ClinGen cosmic curated ClinVar Ensembl NCI-TCGA dbSNP |
|
CA412810358 rs1376896677 |
4 | P>R | No |
ClinGen gnomAD |
|
|
CA412810355 rs1159713948 |
4 | P>S | No |
ClinGen gnomAD |
|
|
rs1048525052 CA329050340 |
5 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA10397910 rs767772118 |
5 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10397911 rs776073253 |
10 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA329050373 rs62636603 |
12 | A>G | No |
ClinGen Ensembl |
|
|
CA412810409 rs1603042042 |
13 | E>D | No |
ClinGen Ensembl |
|
|
rs749564014 CA10397914 COSM422555 |
13 | E>K | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA10397916 rs765492001 |
16 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA10397915 rs201871676 |
16 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1235882605 CA412810428 |
17 | A>S | No |
ClinGen gnomAD |
|
|
rs750598176 CA412810433 |
18 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750598176 CA10397917 |
18 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779656098 CA10397919 |
21 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA10397920 rs746987091 |
22 | K>I | No |
ClinGen ExAC gnomAD |
|
|
rs1431755155 CA412810477 |
25 | L>Q | No |
ClinGen gnomAD |
|
| TCGA novel | 28 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM1121831 rs1398289359 CA412810513 |
30 | R>H | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA412810520 rs1444450941 |
31 | T>M | No |
ClinGen gnomAD |
|
|
rs975645936 CA329050603 |
34 | T>I | No |
ClinGen gnomAD |
|
|
rs1283082877 CA412810581 |
36 | R>G | No |
ClinGen TOPMed |
|
|
CA412810611 rs1210265001 |
38 | G>R | No |
ClinGen TOPMed |
|
|
rs781331960 CA10397939 |
39 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA412810677 rs1292396776 |
42 | Y>C | No |
ClinGen gnomAD |
|
|
CA412810687 rs1569319031 |
43 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA329050631 rs11551157 |
44 | S>F | No |
ClinGen Ensembl |
|
|
rs922510408 CA329050652 |
51 | V>A | No |
ClinGen TOPMed |
|
|
rs1214099265 CA412810801 |
51 | V>L | No |
ClinGen gnomAD |
|
|
rs140920401 CA329050674 |
52 | R>Q | No |
ClinGen ESP gnomAD |
|
|
rs777093232 CA10397942 |
53 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA412810967 rs1413219188 |
63 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1410667957 CA412811126 |
68 | R>L | No |
ClinGen gnomAD |
|
|
rs1410667957 CA412811130 |
68 | R>Q | No |
ClinGen gnomAD |
|
|
rs958658251 CA329051712 |
69 | K>R | No |
ClinGen TOPMed |
|
|
rs199527940 CA10397961 |
70 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs756771141 CA10397963 |
71 | V>F | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 76 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA412811226 rs1375497019 |
77 | A>T | No |
ClinGen gnomAD |
|
|
CA412811236 rs1225438833 |
78 | I>T | No |
ClinGen TOPMed |
|
|
CA10397965 rs745515941 |
84 | E>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 84 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10397967 rs781486338 |
95 | P>Q | No |
ClinGen ExAC |
|
|
rs56197559 VAR_040375 CA329051792 |
98 | M>T | No |
ClinGen UniProt Ensembl dbSNP |
|
|
CA412811475 rs1235697211 |
99 | H>D | No |
ClinGen gnomAD |
|
|
rs1169298813 CA412811492 |
100 | N>D | No |
ClinGen TOPMed |
|
|
rs758004948 CA10397983 |
102 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs1275641708 CA412811578 |
103 | R>W | No |
ClinGen TOPMed |
|
|
rs1263984758 CA412811604 |
105 | T>A | No |
ClinGen gnomAD |
|
|
CA412811682 rs779648831 |
110 | A>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10397985 rs779648831 |
110 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA329051943 rs936264056 |
113 | D>N | No |
ClinGen TOPMed |
|
| TCGA novel | 116 | L>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs756483901 CA10397987 |
119 | L>M | No |
ClinGen ExAC gnomAD |
|
|
CA329051951 rs62636600 |
124 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1267267075 CA412811921 |
127 | T>S | No |
ClinGen gnomAD |
|
|
CA10397988 rs778205718 |
129 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA412812090 rs1199774765 |
139 | K>R | No |
ClinGen gnomAD |
|
|
rs749734176 CA10397989 |
142 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs770926246 CA10397990 |
146 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA10397991 rs774526444 |
150 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774526444 CA329051991 |
150 | N>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746126878 CA10397992 |
151 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1121833 rs1321474185 CA412812254 |
151 | R>H | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs779536112 CA10398008 |
153 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs1297302820 CA412812361 |
154 | F>I | No |
ClinGen gnomAD |
|
|
rs113512925 CA329052177 |
156 | H>Y | No |
ClinGen Ensembl |
|
|
rs745997765 CA10398009 |
157 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA10398011 rs775921012 |
163 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10398012 rs375468186 |
164 | G>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 166 | R>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA412812898 rs1244085978 |
166 | R>K | No |
ClinGen gnomAD |
|
|
rs146376823 CA10398014 |
166 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10398015 rs761480447 |
167 | Q>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs139093707 CA10398018 |
170 | A>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs184861193 CA10398019 |
170 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA329052179 rs1036402369 |
171 | P>A | No |
ClinGen Ensembl |
|
|
rs371247311 CA10398020 |
172 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761931410 CA10398022 |
174 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA412812981 rs1387037979 |
174 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
| TCGA novel | 176 | L>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1157943860 CA412812998 |
176 | L>V | No |
ClinGen gnomAD |
|
|
CA10398025 rs779625869 |
179 | L>S | No |
ClinGen ExAC gnomAD |
|
|
rs1290871003 CA412813042 |
180 | L>V | No |
ClinGen gnomAD |
|
|
CA10398026 rs143159753 |
181 | T>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs958730062 CA329052223 |
184 | G>S | No |
ClinGen TOPMed |
|
|
CA10398040 rs752282820 CA412813164 |
186 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA10398041 rs147086204 |
187 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs138292173 CA10398042 |
188 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10398044 COSM757195 rs777037087 |
188 | R>H | lung Variant assessed as Somatic; 0.0 impact. breast [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA10398043 rs138292173 |
188 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10398046 rs751707690 |
190 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs954175243 CA329053084 |
190 | Q>P | No |
ClinGen TOPMed gnomAD |
|
|
CA10398047 rs372462744 |
191 | H>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA412813219 rs1323645938 |
192 | C>Y | No |
ClinGen gnomAD |
|
|
CA412813236 rs1197389088 CA412813237 |
193 | D>E | No |
ClinGen gnomAD |
|
|
CA10398048 rs781542979 |
194 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780758789 CA10398050 |
200 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs961102008 CA329053113 |
203 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA412813342 rs1470345765 |
205 | A>D | No |
ClinGen gnomAD |
|
|
rs1357153379 CA412813345 |
206 | P>S | No |
ClinGen TOPMed |
|
|
rs774136414 CA10398054 |
208 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA412813368 rs1299239597 |
210 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs923182352 CA329053170 |
211 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
| TCGA novel | 212 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 215 | T>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 218 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA412813414 rs1345707414 |
218 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1217509562 CA412813424 |
219 | H>R | No |
ClinGen gnomAD |
|
|
CA412813459 rs775214073 |
222 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10398057 rs775214073 |
222 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412813488 rs1237333549 |
225 | A>D | No |
ClinGen TOPMed |
|
|
CA412813487 rs1482489991 |
225 | A>S | No |
ClinGen TOPMed |
|
|
CA412813502 rs1205210476 |
226 | P>L | No |
ClinGen gnomAD |
|
|
rs1489802148 CA412813507 |
227 | M>K | No |
ClinGen gnomAD |
|
| TCGA novel | 227 | M>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs747850611 CA10398059 |
227 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1200575485 CA412813522 |
228 | D>N | No |
ClinGen Ensembl |
|
|
rs773749825 CA10398060 |
230 | N>K | No |
ClinGen ExAC gnomAD |
|
|
rs1271359830 CA412813557 |
231 | L>R | No |
ClinGen gnomAD |
|
|
CA412813561 rs1449280704 |
232 | I>L | No |
ClinGen TOPMed |
|
|
rs368024349 CA10398061 |
232 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs771625964 CA10398075 |
235 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA412813660 rs1187147586 |
238 | S>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs746691883 CA10398077 |
238 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10398078 rs148802221 |
239 | F>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs758229241 CA10398092 |
245 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA412813767 rs1456413377 |
246 | S>N | No |
ClinGen TOPMed |
|
| TCGA novel | 247 | R>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA412813840 rs1349543733 |
253 | T>N | No |
ClinGen TOPMed |
|
|
rs996853683 CA329053514 |
253 | T>P | No |
ClinGen Ensembl |
|
|
CA10398094 rs746574967 |
254 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs768276363 CA10398097 |
255 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA10398095 rs1020990103 |
255 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA329053623 rs919593802 |
256 | G>E | No |
ClinGen TOPMed gnomAD |
|
|
CA412813857 rs1409736677 |
256 | G>R | No |
ClinGen gnomAD |
|
|
CA412813879 rs1175260065 |
257 | S>I | No |
ClinGen gnomAD |
|
|
rs747694131 CA10398099 |
261 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA10398100 COSM4149063 rs142304168 |
262 | S>I | ovary [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA412813975 rs1281123703 |
263 | V>A | No |
ClinGen gnomAD |
|
|
rs1439786171 COSM1121835 CA412813969 |
263 | V>M | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA329053671 rs200151563 |
264 | S>Y | No |
ClinGen 1000Genomes |
|
|
rs1229309673 CA412814003 |
265 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA10398104 rs775966352 |
268 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs1321520435 CA412814054 |
268 | K>R | No |
ClinGen gnomAD |
|
| TCGA novel | 268 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA329053681 rs923151586 |
270 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA10398105 rs760815147 |
270 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764098004 CA10398106 |
271 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 271 | H>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10398107 rs754104664 |
274 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs761893348 CA10398108 |
278 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs1285071641 CA412814198 |
278 | Q>L | No |
ClinGen TOPMed |
|
|
CA10398109 rs765113993 |
279 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA329053728 rs1046676785 |
279 | R>H | No |
ClinGen TOPMed |
|
|
rs780206875 CA10398112 |
280 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs145939962 CA10398111 |
280 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10398114 rs754549302 |
281 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10398113 rs372763934 |
281 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 282 | K>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1330804484 CA412814284 |
283 | S>F | No |
ClinGen gnomAD |
|
|
rs747863271 CA10398118 |
285 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA10398117 rs747863271 |
285 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA10398120 rs376276271 |
286 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10398121 rs140123739 |
287 | D>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA412814412 rs1266127841 |
290 | K>Q | No |
ClinGen TOPMed |
|
|
CA10398122 rs775984740 |
291 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA412814524 rs1325945121 |
292 | K>M | No |
ClinGen gnomAD |
|
|
CA10398133 CA10398134 rs781240605 |
293 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412814548 rs1272463628 |
294 | L>V | No |
ClinGen gnomAD |
|
| TCGA novel | 296 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs755638812 CA10398135 |
297 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA10398136 rs371146151 |
301 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA412814733 rs1274776968 |
305 | V>I | No |
ClinGen gnomAD |
|
|
rs780348121 CA10398139 |
306 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412814765 rs1260531101 |
307 | P>S | No |
ClinGen gnomAD |
|
|
rs1177553817 CA412814815 |
309 | E>D | No |
ClinGen TOPMed |
|
|
rs994460893 CA329053903 |
311 | Q>H | No |
ClinGen TOPMed |
|
|
rs143311445 CA10398140 |
312 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 315 | R>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA412814930 rs1198480394 |
315 | R>T | No |
ClinGen TOPMed |
|
|
CA329053909 rs151191170 |
316 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA412814957 rs1161562116 |
317 | G>R | No |
ClinGen gnomAD |
|
|
rs777175765 CA10398142 COSM1121837 |
318 | T>M | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA412814982 rs1164055186 |
319 | G>C | No |
ClinGen gnomAD |
|
|
CA329053945 rs368279563 |
321 | F>L | No |
ClinGen ESP TOPMed |
|
|
rs773318953 CA10398145 |
324 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA412815111 rs1452639448 |
326 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA412815115 rs1313544010 |
326 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs766305105 CA10398147 |
328 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA329053973 rs200106543 |
328 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
| VAR_040376 | 331 | G>C | a colorectal adenocarcinoma sample; somatic mutation [UniProt] | No | UniProt |
|
rs774324085 CA10398148 |
332 | D>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 334 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1206503276 CA412815254 |
335 | V>M | No |
ClinGen gnomAD |
|
|
rs1291075891 CA412815286 |
336 | K>R | No |
ClinGen TOPMed |
|
|
CA412815306 rs1421001199 |
337 | V>A | No |
ClinGen TOPMed |
|
|
rs1460482466 CA412815334 |
339 | K>E | No |
ClinGen gnomAD |
|
|
rs752678087 CA10398151 |
340 | V>M | No |
ClinGen ExAC gnomAD |
|
|
COSM109804 rs150568726 CA329053978 |
345 | A>G | skin [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA412815481 rs1180766366 |
348 | A>T | No |
ClinGen gnomAD |
|
|
CA10398153 rs763604914 |
349 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA10398155 rs756864414 |
353 | N>H | No |
ClinGen ExAC gnomAD |
|
|
CA412815632 rs1335317844 |
357 | V>L | No |
ClinGen gnomAD |
|
|
rs763548006 CA10398170 |
361 | T>M | No |
ClinGen ExAC gnomAD |
|
|
rs756741810 CA10398172 |
362 | R>* | No |
ClinGen ExAC |
|
|
rs1481493209 CA412816014 |
372 | F>Y | No |
ClinGen gnomAD |
|
|
rs145056294 CA10398177 |
375 | R>Q | No |
ClinGen ESP ExAC gnomAD |
|
|
CA10398176 rs755308260 |
375 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA412816064 rs1320336824 |
376 | P>L | No |
ClinGen gnomAD |
|
|
CA412816096 rs1433830281 |
380 | I>T | No |
ClinGen gnomAD |
|
|
rs778119620 CA10398181 |
383 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1363597646 CA412816183 |
385 | C>Y | No |
ClinGen gnomAD |
|
|
rs749435690 CA412816218 |
387 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA10398182 rs749435690 |
387 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA10398183 rs771127790 |
388 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA412816309 rs1309073789 |
392 | H>L | No |
ClinGen TOPMed gnomAD |
|
|
CA412816307 rs1309073789 |
392 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1462354021 CA412816420 |
398 | D>N | No |
ClinGen Ensembl |
|
|
rs754803899 CA10398185 |
400 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs764255925 CA10398186 |
400 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs764255925 CA412816462 |
400 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs760360817 CA10398188 |
403 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 404 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 404 | V>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1194986687 CA412816561 |
405 | Q>H | No |
ClinGen TOPMed |
|
|
CA412816600 rs1483547801 |
408 | D>N | No |
ClinGen TOPMed |
|
|
CA329054911 rs959306158 |
411 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA412816652 rs1290811116 |
411 | R>W | No |
ClinGen gnomAD |
|
|
rs1466145372 CA412816839 |
419 | Y>C | No |
ClinGen gnomAD |
|
|
CA329055005 rs978219080 |
423 | K>E | No |
ClinGen Ensembl |
|
| TCGA novel | 423 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10398205 rs780121164 |
428 | R>* | No |
ClinGen ExAC gnomAD |
|
|
CA412816985 rs1183909266 |
428 | R>L | No |
ClinGen gnomAD |
|
|
rs1183909266 CA412816981 |
428 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 431 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1212825155 CA412817807 |
435 | I>V | No |
ClinGen gnomAD |
|
|
rs373018619 CA10398221 |
444 | K>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10398222 rs750570398 |
445 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA10398224 rs780392848 |
456 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs754787460 CA10398226 |
459 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
| TCGA novel | 461 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs747904029 CA10398228 |
463 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs769771152 CA10398229 |
465 | Q>H | No |
ClinGen ExAC |
|
| TCGA novel | 469 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1157121224 CA412818237 |
478 | I>F | No |
ClinGen TOPMed |
|
|
rs11551158 CA329055521 |
479 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
CA412818251 rs11551158 |
479 | R>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1415064804 CA412818300 |
483 | P>L | No |
ClinGen TOPMed |
|
|
rs1339247916 CA412818296 |
483 | P>S | No |
ClinGen gnomAD |
|
|
rs1474543275 CA412818340 |
487 | S>G | No |
ClinGen TOPMed |
|
|
rs1277297558 CA412818343 |
487 | S>N | No |
ClinGen gnomAD |
|
|
CA412818356 rs1343302524 |
488 | F>Y | No |
ClinGen gnomAD |
|
|
CA329055538 rs1050133 |
489 | Q>* | No |
ClinGen Ensembl |
|
|
rs1452862239 CA412818387 |
491 | D>H | No |
ClinGen gnomAD |
|
|
CA10398244 rs755229896 |
492 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1213294212 CA412818543 |
505 | G>V | No |
ClinGen TOPMed |
|
| TCGA novel | 510 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1130962 CA329055553 |
511 | H>Y | No |
ClinGen Ensembl |
|
| TCGA novel | 512 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs777769604 CA10398248 |
513 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs749120411 CA10398249 |
513 | G>V | No |
ClinGen ExAC |
|
|
CA329055569 rs969755578 |
515 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs773696719 CA10398251 |
515 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745341869 CA10398252 |
517 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs377675069 CA10398272 |
524 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs766573991 CA10398274 |
526 | Y>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs371017890 CA10398273 |
526 | Y>H | No |
ClinGen ESP ExAC gnomAD |
|
|
rs779859676 CA10398275 |
531 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA10398276 rs746605740 |
534 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs1569321394 CA412819064 |
536 | S>G | No |
ClinGen Ensembl |
|
|
CA412819091 rs1603047873 |
537 | N>S | No |
ClinGen Ensembl |
|
|
CA329055933 rs768342528 |
542 | M>T | No |
ClinGen Ensembl |
|
|
CA10398278 rs773486607 |
543 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA10398279 COSM1121848 rs763351013 |
544 | R>C | endometrium Variant assessed as Somatic; 6.336e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA10398280 rs771396364 |
544 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA329055960 rs866481390 |
551 | K>R | No |
ClinGen Ensembl |
|
|
rs979276829 CA329055963 |
554 | R>Q | No |
ClinGen gnomAD |
|
|
CA329055961 rs947894890 |
554 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
rs759617144 CA10398282 |
555 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs760847926 CA10398285 |
562 | Q>* | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 565 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 567 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA412819632 rs1488217404 |
572 | R>Q | No |
ClinGen gnomAD |
|
|
CA412819630 rs1275541592 |
572 | R>W | No |
ClinGen gnomAD |
|
|
rs1189502973 CA412819656 |
574 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
rs1189502973 CA412819651 |
574 | L>I | No |
ClinGen TOPMed gnomAD |
|
|
rs759985490 CA10398301 |
575 | P>T | No |
ClinGen ExAC |
|
|
CA412819683 rs1603048615 |
576 | K>E | No |
ClinGen Ensembl |
|
|
CA329056272 rs979213297 |
576 | K>R | No |
ClinGen Ensembl |
|
|
VAR_040377 CA10398303 rs55852926 RCV000924352 |
578 | E>D | No |
ClinGen ClinVar UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
COSM457561 rs764281834 CA10398305 |
579 | R>Q | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
| TCGA novel | 580 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA329056285 rs866243975 |
581 | A>T | No |
ClinGen Ensembl |
|
|
CA412819846 rs1168869454 |
588 | R>C | No |
ClinGen gnomAD |
|
|
rs776912006 CA10398306 |
588 | R>H | No |
ClinGen ExAC |
|
|
rs750411643 CA412820043 |
602 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs750411643 CA10398311 |
602 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1228819643 CA412820051 |
603 | R>C | No |
ClinGen gnomAD |
6 associated diseases with P10398
[MIM: 137800]: Glioma (GLM)
Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. {ECO:0000269|PubMed:15457249}. Note=The gene represented in this entry is involved in disease pathogenesis.
[MIM: 167000]: Ovarian cancer (OC)
The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO:0000269|PubMed:15457249, ECO:0000269|PubMed:17344846}. Note=The gene represented in this entry is involved in disease pathogenesis.
[MIM: 211980]: Lung cancer (LNCR)
A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes
[MIM: 613659]: Gastric cancer (GASC)
A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269|PubMed:15457249, ECO:0000269|PubMed:17344846}. Note=The protein represented in this entry is involved in disease pathogenesis.
[MIM: 619465]: Visceral neuropathy, familial, 2, autosomal recessive (VSCN2)
An autosomal recessive disorder characterized by intestinal dysmotility due to aganglionosis (Hirschsprung disease), hypoganglionosis, and/or chronic intestinal pseudoobstruction. Patients also show peripheral axonal neuropathy, hypotonia, mild developmental delay, unilateral ptosis, and sensorineural hearing loss. {ECO:0000269|PubMed:33497358}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. {ECO:0000269|PubMed:15457249}. Note=The gene represented in this entry is involved in disease pathogenesis.
- The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO:0000269|PubMed:15457249, ECO:0000269|PubMed:17344846}. Note=The gene represented in this entry is involved in disease pathogenesis.
- A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes
- A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269|PubMed:15457249, ECO:0000269|PubMed:17344846}. Note=The protein represented in this entry is involved in disease pathogenesis.
- An autosomal recessive disorder characterized by intestinal dysmotility due to aganglionosis (Hirschsprung disease), hypoganglionosis, and/or chronic intestinal pseudoobstruction. Patients also show peripheral axonal neuropathy, hypotonia, mild developmental delay, unilateral ptosis, and sensorineural hearing loss. {ECO:0000269|PubMed:33497358}. Note=The disease is caused by variants affecting the gene represented in this entry.
4 regional properties for P10398
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 14 - 272 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 132 - 144 | IPR008271 |
| domain | Calcium/calmodulin-dependent protein kinase II, association-domain | 395 - 522 | IPR013543 |
| binding_site | Protein kinase, ATP binding site | 20 - 43 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
| metal ion binding | Binding to a metal ion. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of peptidyl-serine phosphorylation | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
| protein modification process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of proteasomal ubiquitin-dependent protein catabolic process | Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| regulation of TOR signaling | Any process that modulates the frequency, rate or extent of TOR signaling. |
21 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A7E3S4 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Bos taurus (Bovine) | SS |
| Q04982 | BRAF | Serine/threonine-protein kinase B-raf | Gallus gallus (Chicken) | SS |
| P05625 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Gallus gallus (Chicken) | PR |
| P11346 | Raf | Raf homolog serine/threonine-protein kinase Raf | Drosophila melanogaster (Fruit fly) | PR |
| O43353 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | Homo sapiens (Human) | PR |
| Q02779 | MAP3K10 | Mitogen-activated protein kinase kinase kinase 10 | Homo sapiens (Human) | SS |
| P80192 | MAP3K9 | Mitogen-activated protein kinase kinase kinase 9 | Homo sapiens (Human) | SS |
| Q16584 | MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 | Homo sapiens (Human) | EV |
| Q13418 | ILK | Integrin-linked protein kinase | Homo sapiens (Human) | PR |
| P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens (Human) | EV |
| P15056 | BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens (Human) | EV |
| Q8NB16 | MLKL | Mixed lineage kinase domain-like protein | Homo sapiens (Human) | EV |
| P28028 | Braf | Serine/threonine-protein kinase B-raf | Mus musculus (Mouse) | SS |
| Q99N57 | Raf1 | RAF proto-oncogene serine/threonine-protein kinase | Mus musculus (Mouse) | SS |
| P04627 | Araf | Serine/threonine-protein kinase A-Raf | Mus musculus (Mouse) | PR |
| O19004 | ARAF | Serine/threonine-protein kinase A-Raf | Sus scrofa (Pig) | PR |
| P11345 | Raf1 | RAF proto-oncogene serine/threonine-protein kinase | Rattus norvegicus (Rat) | SS |
| P14056 | Araf | Serine/threonine-protein kinase A-Raf | Rattus norvegicus (Rat) | PR |
| Q07292 | lin-45 | Raf homolog serine/threonine-protein kinase | Caenorhabditis elegans | PR |
| Q05609 | CTR1 | Serine/threonine-protein kinase CTR1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FPR3 | EDR1 | Serine/threonine-protein kinase EDR1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPPRGPPAN | GAEPSRAVGT | VKVYLPNKQR | TVVTVRDGMS | VYDSLDKALK | VRGLNQDCCV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VYRLIKGRKT | VTAWDTAIAP | LDGEELIVEV | LEDVPLTMHN | FVRKTFFSLA | FCDFCLKFLF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HGFRCQTCGY | KFHQHCSSKV | PTVCVDMSTN | RQQFYHSVQD | LSGGSRQHEA | PSNRPLNELL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TPQGPSPRTQ | HCDPEHFPFP | APANAPLQRI | RSTSTPNVHM | VSTTAPMDSN | LIQLTGQSFS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TDAAGSRGGS | DGTPRGSPSP | ASVSSGRKSP | HSKSPAEQRE | RKSLADDKKK | VKNLGYRDSG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YYWEVPPSEV | QLLKRIGTGS | FGTVFRGRWH | GDVAVKVLKV | SQPTAEQAQA | FKNEMQVLRK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TRHVNILLFM | GFMTRPGFAI | ITQWCEGSSL | YHHLHVADTR | FDMVQLIDVA | RQTAQGMDYL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HAKNIIHRDL | KSNNIFLHEG | LTVKIGDFGL | ATVKTRWSGA | QPLEQPSGSV | LWMAAEVIRM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QDPNPYSFQS | DVYAYGVVLY | ELMTGSLPYS | HIGCRDQIIF | MVGRGYLSPD | LSKISSNCPK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AMRRLLSDCL | KFQREERPLF | PQILATIELL | QRSLPKIERS | ASEPSLHRTQ | ADELPACLLS |
| AARLVP |