AiPD: Autoinhibited Protein Database

P10242

Gene name	MYB
Protein name	Transcriptional activator Myb
Names	Proto-oncogene c-Myb
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4602
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-50 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P10242

Entry ID	Method	Resolution	Chain	Position	Source
AF-P10242-F1	Predicted				AlphaFoldDB

374 variants for P10242

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1226644001 CA365732425	6	R>G		No	ClinGen TOPMed
CA365732429 rs1358619520	6	R>Q		No	ClinGen TOPMed
rs768018541 CA4011225	9	I>T		No	ClinGen ExAC TOPMed
CA4011224 rs759941238	9	I>V		No	ClinGen ExAC TOPMed gnomAD
CA148138546 rs112799998	11	S>G		No	ClinGen Ensembl
rs967344622 CA148138563	12	S>C		No	ClinGen TOPMed
rs1222801619 CA365733849	12	S>N		No	ClinGen gnomAD
CA365733861 rs756361507	13	D>E		No	ClinGen ExAC TOPMed gnomAD
CA4011229 rs753940197	14	E>G		No	ClinGen ExAC gnomAD
CA4011228 rs777923027	14	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	15	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs980292268 CA148138573	18	D>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1288365750 CA365733920	21	M>I		No	ClinGen TOPMed gnomAD
rs778787538 CA4011231	21	M>T		No	ClinGen ExAC gnomAD
rs745832879 CA4011232	24	H>N		No	ClinGen ExAC TOPMed gnomAD
rs771802758 CA4011233	24	H>R		No	ClinGen ExAC gnomAD
CA148138593 rs568057920	30	L>V		No	ClinGen Ensembl
rs1426416522 CA365733995	32	K>R		No	ClinGen gnomAD
CA4011235 rs746848743	34	G>R		No	ClinGen ExAC gnomAD
CA4011237 rs776200677	36	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA365734020 rs1451326893	36	R>H		No	ClinGen gnomAD
CA365734027 rs761355498	37	H>P		No	ClinGen ExAC gnomAD
rs761355498 CA4011238	37	H>R		No	ClinGen ExAC gnomAD
CA365734059 rs1343042048	42	R>K		No	ClinGen gnomAD
CA365734080 rs1403836963	45	R>W		No	ClinGen gnomAD
CA4011261 rs772851313	49	E>Q		No	ClinGen ExAC gnomAD
rs762617064 CA4011262	50	K>R		No	ClinGen ExAC gnomAD
rs772692025 CA4011263	52	K>R		No	ClinGen ExAC
rs149280002 CA4011264	53	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1276513639 CA365734164	56	E>K		No	ClinGen TOPMed
CA4011265 rs761065191	57	Q>E		No	ClinGen ExAC gnomAD
rs1182150969 CA365734184	58	N>S		No	ClinGen gnomAD
TCGA novel	60	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1385070053 CA365734203	61	D>G		No	ClinGen gnomAD
rs1460905406 CA365734199	61	D>N		No	ClinGen gnomAD
CA365734207 COSM1544890 rs1443630742 COSM1544891	62	D>N	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	63	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4011266 rs764394253	65	V>G		No	ClinGen ExAC TOPMed gnomAD
CA365734244 rs1346403712	67	A>T		No	ClinGen gnomAD
rs1437060412 CA365734254	68	N>S		No	ClinGen TOPMed
TCGA novel	70	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4011268 rs762033472	71	P>L		No	ClinGen ExAC TOPMed gnomAD
rs762033472 CA365734274	71	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs776861167 CA4011267	71	P>S		No	ClinGen ExAC gnomAD
CA365734291 rs1391099064	72	N>T		No	ClinGen gnomAD
rs1302072057 CA365734300	73	R>L		No	ClinGen gnomAD
CA365734298 rs1302072057	73	R>Q		No	ClinGen gnomAD
CA4011288 rs762224204	75	D>E		No	ClinGen ExAC TOPMed gnomAD
CA365734319 rs1249393095	76	V>G		No	ClinGen gnomAD
rs866246271 CA148141612	78	C>Y		No	ClinGen Ensembl
rs1222164414 CA365734336	79	Q>E		No	ClinGen gnomAD
rs1294298826 CA365734349	80	H>Q		No	ClinGen TOPMed
TCGA novel	81	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4011289 rs765423956	82	W>*		No	ClinGen ExAC gnomAD
CA365734373 rs1246761830	84	K>E		No	ClinGen TOPMed
TCGA novel	85	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	85	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365734444 rs1231582413	94	P>R		No	ClinGen gnomAD
TCGA novel	97	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs918848380 CA148141618	102	R>K		No	ClinGen TOPMed gnomAD
CA4011312 rs763178718	105	E>A		No	ClinGen ExAC gnomAD
TCGA novel	110	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365734568 rs1433475831	110	Y>H		No	ClinGen gnomAD
rs1361650612 CA365734575	111	G>S		No	ClinGen gnomAD
CA4011314 rs774287821	114	R>H		No	ClinGen ExAC TOPMed gnomAD
rs752717882 CA4011317	117	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1562368330 CA365734616	117	V>F		No	ClinGen Ensembl
rs758450259 CA148141854	118	I>V		No	ClinGen Ensembl
TCGA novel	123	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1408745338 CA365735122	153	R>T		No	ClinGen gnomAD
CA365735193 rs1316378738	158	A>E		No	ClinGen TOPMed gnomAD
CA365735190 rs1316774942	158	A>T		No	ClinGen gnomAD
CA4011328 rs778119027	170	A>S		No	ClinGen ExAC gnomAD
COSM168375 CA365735358 COSM168374 rs778119027	170	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA4011329 rs749730179	176	R>*		No	ClinGen ExAC gnomAD
CA365735416 rs1583273308	176	R>Q		No	ClinGen Ensembl
TCGA novel	179	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365735478 rs1179275735	183	N>S		No	ClinGen gnomAD
CA365735525 rs1340781737	189	M>I		No	ClinGen TOPMed
CA365735537 COSM3430031 rs1335964521 COSM3430032	191	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA365735540 rs1444007668	192	K>E		No	ClinGen gnomAD
rs1380159781 CA365735556	194	E>A		No	ClinGen TOPMed
rs1342064644 CA365735559	194	E>D		No	ClinGen TOPMed
TCGA novel	194	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1223989139 CA365735592	199	L>V		No	ClinGen gnomAD
CA365735601 rs1264962110	200	Q>L		No	ClinGen gnomAD
rs1583283788 CA365735614	202	S>A		No	ClinGen Ensembl
CA365735632 rs1321068669	205	A>T		No	ClinGen gnomAD
CA4011348 rs143011739	209	A>G		No	ClinGen ESP ExAC TOPMed
CA365735660 rs1298243557	209	A>T		No	ClinGen TOPMed
CA148143633 rs776218526	210	V>A		No	ClinGen Ensembl
CA365735674 rs1363192481	211	A>G		No	ClinGen TOPMed
CA365735681 rs1583283899	212	T>I		No	ClinGen Ensembl
rs746123937 CA4011350	213	S>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	213	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365735706 rs1458870370	216	K>E		No	ClinGen TOPMed
CA148143670 rs950607758	216	K>R		No	ClinGen TOPMed gnomAD
CA365735777 rs1562371015	225	Q>H		No	ClinGen Ensembl
rs775714562 CA4011352	225	Q>R		No	ClinGen ExAC gnomAD
rs374588074 CA4011353	226	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA4011354 rs768694674	226	A>V		No	ClinGen ExAC gnomAD
CA4011356 rs146156073	227	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs539769963 CA148143798	230	A>P		No	ClinGen 1000Genomes gnomAD
CA4011358 rs772687021	231	Q>H		No	ClinGen ExAC
CA148143818 rs1023586066	232	L>F		No	ClinGen Ensembl
rs762675122 CA4011359	232	L>P		No	ClinGen ExAC gnomAD
rs766089394 CA4011360	234	A>G		No	ClinGen ExAC TOPMed gnomAD
rs766089394 CA365735826	234	A>V		No	ClinGen ExAC TOPMed gnomAD
CA365735833 rs1343552963	236	G>S		No	ClinGen gnomAD
rs754529781 CA365735859	240	V>F		No	ClinGen ExAC gnomAD
CA4011362 rs754529781	240	V>I		No	ClinGen ExAC gnomAD
CA148143856 rs963252355	243	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA365735890 rs974068084	244	Y>C		No	ClinGen TOPMed gnomAD
CA148143885 rs974068084	244	Y>S		No	ClinGen TOPMed gnomAD
CA4011364 rs754396975	248	H>D		No	ClinGen ExAC gnomAD
rs1358636440 CA365735942	251	E>D		No	ClinGen Ensembl
CA4011385 rs142284572	255	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA4011386 rs758875916	258	H>R		No	ClinGen ExAC gnomAD
CA4011387 rs780385476	259	V>F		No	ClinGen ExAC gnomAD
CA365736055 rs780385476	259	V>I		No	ClinGen ExAC gnomAD
rs1583291126 CA365736079	261	Y>S		No	ClinGen Ensembl
rs1477052128 CA365736111	264	A>T		No	ClinGen TOPMed
TCGA novel	265	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365736143 rs1200844623	266	H>R		No	ClinGen TOPMed
CA4011389 rs755051321	266	H>Y		No	ClinGen ExAC gnomAD
rs778761961 CA148145143	269	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs781340500 CA4011390	269	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1382802408 CA365736210	271	N>S		No	ClinGen gnomAD
CA148145153 rs987578256	275	P>S		No	ClinGen TOPMed gnomAD
rs769759766 CA365736296	278	A>S		No	ClinGen ExAC TOPMed gnomAD
rs769759766 CA4011394	278	A>T		No	ClinGen ExAC TOPMed gnomAD
rs770741732 CA4011397	279	A>G		No	ClinGen ExAC gnomAD
rs749049169 CA4011396	279	A>T		No	ClinGen ExAC gnomAD
CA4011406 rs151255794	282	R>T		No	ClinGen ESP ExAC gnomAD
CA365736754 rs1159185118	288	D>E		No	ClinGen TOPMed gnomAD
TCGA novel	298	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	304	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755251168 CA4011408	305	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	306	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365736905 rs1334896911	310	K>E		No	ClinGen gnomAD
CA4011411 rs756191927	314	V>M		No	ClinGen ExAC gnomAD
CA4011412 rs73774602	315	L>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs369681525 CA4011448	317	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA365737090 rs1192209516	320	H>Y		No	ClinGen TOPMed
CA365737121 rs1274003953	322	C>G		No	ClinGen TOPMed
CA4011449 rs760807701	322	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA4011450 rs764366080	324	Y>D		No	ClinGen ExAC gnomAD
CA4011451 rs753900884	325	P>H		No	ClinGen ExAC gnomAD
rs1162709348 CA365737176	325	P>S		No	ClinGen gnomAD
rs750351406 COSM204589 CA4011454 COSM204588	326	G>R	large_intestine Variant assessed as Somatic; 4.621e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1157606106 CA365737222	327	W>C		No	ClinGen gnomAD
CA4011455 rs758156067	329	S>N		No	ClinGen ExAC gnomAD
CA365737299 rs1438379621	332	I>V		No	ClinGen TOPMed
COSM134149 rs373144674 COSM134148 CA4011458	334	D>N	oesophagus skin [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
rs747633726 CA4011460	335	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs375651983 CA4011459	335	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_050188 RCV000905518 rs2229999 CA4011461	336	T>I		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1283080621 CA365737364	336	T>S		No	ClinGen gnomAD
CA4011464 rs772410551	337	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1410998536 CA365737412	339	H>L		No	ClinGen TOPMed
rs775709886 CA4011465	339	H>Q		No	ClinGen ExAC gnomAD
rs1394961307 CA365737468	342	S>T		No	ClinGen TOPMed
rs1172354835 CA365737518	345	V>A		No	ClinGen TOPMed
rs267600823 CA4011466	346	S>F		No	ClinGen ExAC gnomAD
CA4011467 rs764278331	349	G>E		No	ClinGen ExAC gnomAD
rs776876145 CA4011468	350	E>G		No	ClinGen ExAC gnomAD
CA4011469 rs761839406	351	H>N		No	ClinGen ExAC gnomAD
rs765315652 CA4011470	351	H>Q		No	ClinGen ExAC gnomAD
rs750310093 CA4011471	353	S>Y		No	ClinGen ExAC gnomAD
CA365737588 rs1411902573	354	T>N		No	ClinGen gnomAD
CA365737590 rs1411902573	354	T>S		No	ClinGen gnomAD
CA4011472 rs758263932	355	P>L		No	ClinGen ExAC TOPMed gnomAD
rs972074114 CA148146834	356	S>P		No	ClinGen TOPMed gnomAD
rs1400595151 CA365737608	358	P>S		No	ClinGen gnomAD
rs141379276 CA4011473	359	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA365737623 rs1562375725	360	D>E		No	ClinGen Ensembl
rs780955537 CA4011476	362	G>D		No	ClinGen ExAC TOPMed gnomAD
CA365737640 rs1279471374	363	S>C		No	ClinGen TOPMed
CA365737648 rs1222705214	365	P>A		No	ClinGen gnomAD
CA365737670 rs1307163881	368	S>G		No	ClinGen TOPMed gnomAD
rs752423593 CA148146851	368	S>R		No	ClinGen ExAC TOPMed gnomAD
rs199722406 CA4011478	369	A>T		No	ClinGen ExAC TOPMed gnomAD
rs375429026 CA148146858	370	S>L		No	ClinGen ESP TOPMed gnomAD
rs375429026 CA148146857	370	S>W		No	ClinGen ESP TOPMed gnomAD
rs967109190 CA148146859	372	A>T		No	ClinGen TOPMed gnomAD
rs1272273723 CA365737702	373	R>S		No	ClinGen gnomAD
rs776677290 CA148146874	375	M>I		No	ClinGen Ensembl
rs772444343 CA4011481	376	I>F		No	ClinGen ExAC gnomAD
rs780660118 CA365737724	376	I>M		No	ClinGen ExAC TOPMed gnomAD
rs747304465 CA4011483	378	H>R		No	ClinGen ExAC gnomAD
rs769038941 CA4011484	380	G>D		No	ClinGen ExAC gnomAD
rs762027315 CA4011486	387	K>T		No	ClinGen ExAC gnomAD
rs1376219508 CA365737868	397	Q>H		No	ClinGen gnomAD
rs145124572 CA4011487	398	F>C		No	ClinGen ESP ExAC gnomAD
CA365737881 rs1215728054	399	I>T		No	ClinGen gnomAD
rs1167673295 CA365739701	407	S>R		No	ClinGen TOPMed
rs779846789 CA148149875	409	H>R		No	ClinGen gnomAD
TCGA novel	410	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1391566299 CA365739734	411	N>D		No	ClinGen TOPMed
CA4011604 rs771502816	412	S>P		No	ClinGen ExAC gnomAD
rs777137022 CA4011605	414	L>F		No	ClinGen ExAC TOPMed gnomAD
CA4011606 rs762413226	415	E>D		No	ClinGen ExAC gnomAD
rs200639167 CA4011608	416	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4011607 rs765910984	416	M>V		No	ClinGen ExAC gnomAD
CA365739775 rs1264735984	417	P>S		No	ClinGen TOPMed
rs1490671095 CA365739784	418	S>F		No	ClinGen TOPMed
rs763451124 CA4011609	418	S>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	418	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200899383 CA148149965	421	S>C		No	ClinGen TOPMed
rs2230000 CA365739807	422	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000879694 VAR_050189 rs2230000 CA4011610	422	T>N		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs755029331 CA4011612	423	P>A		No	ClinGen ExAC gnomAD
CA4011613 rs377014519	423	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA365739812 rs756037127	424	L>F		No	ClinGen ExAC TOPMed gnomAD
CA4011617 rs749047464	424	L>H		No	ClinGen ExAC
rs756037127 CA4011615	424	L>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	424	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756037127 CA4011616	424	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	425	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365739820 rs1250445633	425	I>S		No	ClinGen Ensembl
CA365739819 rs1250445633	425	I>T		No	ClinGen Ensembl
rs1346027915 CA365739832	427	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs745518375 CA4011620	430	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1203580616 CA365739866	432	T>K		No	ClinGen TOPMed gnomAD
rs1452740695 CA365739890	436	H>Y		No	ClinGen gnomAD
rs143010463 CA4011624	438	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs746567028 CA4011623	438	D>H		No	ClinGen ExAC gnomAD
CA365739915 rs1172634373	439	Q>H		No	ClinGen gnomAD
rs1476805948 CA365739911	439	Q>K		No	ClinGen gnomAD
CA365739918 rs1465270168	440	T>A		No	ClinGen TOPMed
CA365739925 rs1431127651	441	V>L		No	ClinGen TOPMed gnomAD
CA365739924 rs1431127651	441	V>M		No	ClinGen TOPMed gnomAD
CA4011625 rs773888577	442	K>I		No	ClinGen ExAC
TCGA novel	443	T>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4011626 rs763362623	443	T>S		No	ClinGen ExAC gnomAD
rs1395649197 CA365739944	444	Q>P		No	ClinGen gnomAD
rs773276636 CA148150115	445	K>Q		No	ClinGen Ensembl
CA365739952 rs1325263166	445	K>R		No	ClinGen gnomAD
rs763153391 CA148150128	449	V>A		No	ClinGen Ensembl
CA365740017 rs1247579811	453	P>S		No	ClinGen gnomAD
rs779796852 CA4011641	455	I>F		No	ClinGen ExAC TOPMed gnomAD
CA4011642 rs779796852	455	I>V		No	ClinGen ExAC TOPMed gnomAD
rs146755940 CA148150728	456	K>*		No	ClinGen 1000Genomes
rs768305061 CA4011643	458	S>A		No	ClinGen ExAC gnomAD
rs1465967713 CA365740057	459	I>M		No	ClinGen TOPMed gnomAD
CA365740055 rs1270493960	459	I>T		No	ClinGen gnomAD
CA148150738 rs956364900	459	I>V		No	ClinGen Ensembl
rs1203017096 CA365740061	460	L>S		No	ClinGen TOPMed gnomAD
rs1299620822 CA365740071	461	E>D		No	ClinGen gnomAD
CA4011644 rs778369825	461	E>G		No	ClinGen ExAC gnomAD
rs1260349935 CA365740065	461	E>K		No	ClinGen gnomAD
rs1415546608 CA365740092	465	R>G		No	ClinGen gnomAD
rs749820799 CA4011645	465	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA365740109 rs1364246936	467	P>L		No	ClinGen TOPMed
rs1369017132 CA365740106	467	P>S		No	ClinGen TOPMed gnomAD
rs771538068 CA4011646	468	T>A		No	ClinGen ExAC gnomAD
CA148150773 rs1042484593	472	H>R		No	ClinGen TOPMed
CA4011650 rs775717051	473	A>P		No	ClinGen ExAC TOPMed gnomAD
CA4011653 rs756830286	482	G>S		No	ClinGen ExAC TOPMed gnomAD
rs55926915 CA4011654	483	P>S		No	ClinGen ExAC TOPMed gnomAD
rs55926915 CA365740211	483	P>T		No	ClinGen ExAC TOPMed gnomAD
rs765275871 CA4011655	484	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1236382279 CA365740224	485	K>R		No	ClinGen TOPMed gnomAD
CA148150868 rs900245440	486	M>L		No	ClinGen TOPMed gnomAD
rs997333176 CA148150871	486	M>R		No	ClinGen TOPMed gnomAD
rs900245440 CA365740229	486	M>V		No	ClinGen TOPMed gnomAD
rs1254857848 CA365740238	487	L>P		No	ClinGen gnomAD
CA365740254 rs1176411413	488	P>S		No	ClinGen TOPMed gnomAD
rs765046065 CA4011674	489	Q>E		No	ClinGen ExAC gnomAD
CA365740275 rs750397896	491	P>H		No	ClinGen ExAC TOPMed gnomAD
rs750397896 CA4011675	491	P>L		No	ClinGen ExAC TOPMed gnomAD
CA365740286 rs766283026	493	H>L		No	ClinGen ExAC TOPMed gnomAD
CA4011677 rs766283026	493	H>R		No	ClinGen ExAC TOPMed gnomAD
CA4011678 rs751469115	495	V>I		No	ClinGen ExAC gnomAD
COSM739999 COSM740000 CA365740309 rs1294474255	497	D>Y	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1370196556 CA365740346	502	I>T		No	ClinGen gnomAD
rs1251601513 CA365740378	506	S>F		No	ClinGen TOPMed
CA4011681 rs73555746	508	E>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs113182184 CA4011682 COSM421070 COSM421069	510	G>E	urinary_tract [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA365740472 rs1310577408	520	P>S		No	ClinGen TOPMed
CA4011684 rs746403738	522	L>F		No	ClinGen ExAC gnomAD
TCGA novel	523	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365740507 rs1583328447	525	K>N		No	ClinGen Ensembl
CA4011685 rs758697644	525	K>R		No	ClinGen ExAC gnomAD
rs1281291924 CA365740520	527	K>R		No	ClinGen TOPMed
rs1562382372 CA365740526	528	Q>R		No	ClinGen Ensembl
CA365740629 rs1328235941	530	V>A		No	ClinGen gnomAD
rs371729193 CA4011731	531	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1442824017 CA365740637	531	E>D		No	ClinGen TOPMed
TCGA novel	531	E>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4011732 rs778940362	537	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1396319202 CA365740702	539	N>H		No	ClinGen gnomAD
rs376614277 CA4011733	540	F>I		No	ClinGen ESP ExAC TOPMed
rs771972764 CA4011734	540	F>Y		No	ClinGen ExAC TOPMed gnomAD
CA4011736 rs112653372	543	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4011735 rs775343566	543	S>P		No	ClinGen ExAC gnomAD
rs1326542787 CA365740780	544	H>D		No	ClinGen TOPMed gnomAD
rs1326542787 CA365740778	544	H>N		No	ClinGen TOPMed gnomAD
CA148152100 rs372904776	544	H>R		No	ClinGen ESP TOPMed gnomAD
CA4011739 rs369628182	548	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	549	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4011740 rs764731225	550	S>R		No	ClinGen ExAC gnomAD
CA4011741 rs750000035	550	S>R		No	ClinGen ExAC gnomAD
CA148152178 rs958553931	555	L>P		No	ClinGen TOPMed
rs1272659280 CA365741005	556	F>L		No	ClinGen gnomAD
COSM245839 CA4011744 rs374987126 COSM245840	557	T>M	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs756463754 CA4011745	558	Q>R		No	ClinGen ExAC gnomAD
rs777999385 CA4011746	559	T>A		No	ClinGen ExAC
CA365741047 rs777999385	559	T>P		No	ClinGen ExAC
rs754130347 CA4011747	559	T>S		No	ClinGen ExAC gnomAD
rs550014418 CA4011748	560	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs991310044 CA148152226	562	V>M		No	ClinGen TOPMed
rs989453196 CA148152259	563	A>P		No	ClinGen TOPMed gnomAD
CA148152286 rs1020865987	564	D>Y		No	ClinGen Ensembl
rs746005763 CA4011750	565	A>V		No	ClinGen ExAC
TCGA novel CA365741163 rs1583339371	566	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA4011751 rs772026403	566	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1346556189 CA365742347	567	N>D		No	ClinGen gnomAD
rs1305740100 CA365742413	570	T>K		No	ClinGen gnomAD
rs568000053 CA4011790	573	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1583351716 CA365742483	575	M>T		No	ClinGen Ensembl
CA365742495 rs1212057861	577	P>S		No	ClinGen gnomAD
rs781145531 CA4011791	578	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1036156896 CA148153544	578	A>V		No	ClinGen Ensembl
CA4011793 rs755921035	579	S>L		No	ClinGen ExAC gnomAD
rs370301077 CA148153578	579	S>T		No	ClinGen gnomAD
CA4011794 rs777345988	580	E>A		No	ClinGen ExAC gnomAD
rs1257694278 CA365742507	580	E>K		No	ClinGen TOPMed gnomAD
CA365742521 rs777345988	580	E>V		No	ClinGen ExAC gnomAD
CA4011795 rs748900859	581	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1420481378 CA365742537	582	E>K		No	ClinGen gnomAD
CA4011796 rs770687886	583	D>G		No	ClinGen ExAC gnomAD
CA365742555 rs1462656853	583	D>H		No	ClinGen gnomAD
TCGA novel	585	V>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777310468 CA4011800	590	T>I		No	ClinGen ExAC TOPMed gnomAD
CA4011799 rs769256842	590	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1180691311 CA365742676	591	V>A		No	ClinGen TOPMed
TCGA novel	594	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365742715 rs1192007361	594	N>T		No	ClinGen gnomAD
CA365742732 rs1399343498	595	R>T		No	ClinGen gnomAD
rs114298899 CA4011805	598	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs114298899 CA4011804	598	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA365742797 rs1317785370	600	P>L		No	ClinGen gnomAD
rs1305713629 CA365743866	603	P>S		No	ClinGen TOPMed
CA4011850 rs544172826	606	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs377634719 CA4011851	606	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs561459986 CA4011854	610	P>A		No	ClinGen 1000Genomes ExAC gnomAD
rs561459986 CA4011855	610	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs978966227 CA148163535	612	S>P		No	ClinGen Ensembl
rs1348916847 CA365743933	613	C>G		No	ClinGen gnomAD
rs61753805 CA4011856	613	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs776655417 CA4011857	614	G>E		No	ClinGen ExAC gnomAD
TCGA novel	614	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765085584 CA4011859	616	M>T		No	ClinGen ExAC TOPMed gnomAD
CA4011858 rs761459969	616	M>V		No	ClinGen ExAC gnomAD
rs750311598 CA4011860	617	E>K		No	ClinGen ExAC gnomAD
CA365743965 rs1422665014	618	E>K		No	ClinGen gnomAD
TCGA novel	619	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365743984 rs1462131123	620	M>T		No	ClinGen gnomAD
CA365743995 rs1297117753	621	T>I		No	ClinGen TOPMed
CA4011861 rs758101576	622	S>P		No	ClinGen ExAC gnomAD
rs148508251 CA4011862	623	S>C		No	ClinGen ESP ExAC gnomAD
CA365744010 rs751072359	624	S>I		No	ClinGen ExAC TOPMed gnomAD
CA4011863 rs751072359	624	S>T		No	ClinGen ExAC TOPMed gnomAD
CA148163591 rs111414491	627	R>C		No	ClinGen ESP TOPMed gnomAD
rs200859137 CA4011867	627	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4011866 rs200859137	627	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147282507 CA4011868	629	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA365744045 rs1353905178	630	V>M		No	ClinGen gnomAD
CA365744071 rs1448598848	633	F>L		No	ClinGen gnomAD
rs753515419 CA148163624	636	R>Q		No	ClinGen TOPMed gnomAD
COSM3941518 rs747043685 COSM3941519 COSM3941520 CA4011872	637	T>M	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
TCGA novel	637	T>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4011874 rs776365497	638	L>V		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with P10242

8 regional properties for P10242

Type	Name	Position	InterPro Accession
domain	SANT/Myb domain	35 - 88	IPR001005-1
domain	SANT/Myb domain	87 - 140	IPR001005-2
domain	SANT/Myb domain	139 - 191	IPR001005-3
domain	Transcription regulator Wos2-domain	268 - 313	IPR012642
domain	C-myb, C-terminal	398 - 556	IPR015395
domain	Myb domain	35 - 86	IPR017930-1
domain	Myb domain	87 - 142	IPR017930-2
domain	Myb domain	143 - 193	IPR017930-3

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase II transcription regulator complex	A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.

3 GO annotations of molecular function

Name	Definition
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

15 GO annotations of biological process

Name	Definition
chromatin remodeling	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
erythrocyte differentiation	The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
myeloid cell development	The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of hematopoietic progenitor cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation.
negative regulation of megakaryocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of histone H3-K4 methylation	Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.
positive regulation of histone H3-K9 methylation	Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.
positive regulation of miRNA transcription	Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription.
positive regulation of T-helper cell differentiation	Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q4JL76	MYBAS2	Myb-related protein MYBAS2	Oryza sativa subsp japonica (Rice)	PR

10	20	30	40	50	60
MARRPRHSIY	SSDEDDEDFE	MCDHDYDGLL	PKSGKRHLGK	TRWTREEDEK	LKKLVEQNGT
70	80	90	100	110	120
DDWKVIANYL	PNRTDVQCQH	RWQKVLNPEL	IKGPWTKEED	QRVIELVQKY	GPKRWSVIAK
130	140	150	160	170	180
HLKGRIGKQC	RERWHNHLNP	EVKKTSWTEE	EDRIIYQAHK	RLGNRWAEIA	KLLPGRTDNA
190	200	210	220	230	240
IKNHWNSTMR	RKVEQEGYLQ	ESSKASQPAV	ATSFQKNSHL	MGFAQAPPTA	QLPATGQPTV
250	260	270	280	290	300
NNDYSYYHIS	EAQNVSSHVP	YPVALHVNIV	NVPQPAAAAI	QRHYNDEDPE	KEKRIKELEL
310	320	330	340	350	360
LLMSTENELK	GQQVLPTQNH	TCSYPGWHST	TIADHTRPHG	DSAPVSCLGE	HHSTPSLPAD
370	380	390	400	410	420
PGSLPEESAS	PARCMIVHQG	TILDNVKNLL	EFAETLQFID	SFLNTSSNHE	NSDLEMPSLT
430	440	450	460	470	480
STPLIGHKLT	VTTPFHRDQT	VKTQKENTVF	RTPAIKRSIL	ESSPRTPTPF	KHALAAQEIK
490	500	510	520	530	540
YGPLKMLPQT	PSHLVEDLQD	VIKQESDESG	IVAEFQENGP	PLLKKIKQEV	ESPTDKSGNF
550	560	570	580	590	600
FCSHHWEGDS	LNTQLFTQTS	PVADAPNILT	SSVLMAPASE	DEDNVLKAFT	VPKNRSLASP
610	620	630
LQPCSSTWEP	ASCGKMEEQM	TSSSQARKYV	NAFSARTLVM