P0DMA5

PR
Gene name
Scn10a (Sns)
Protein name
Sodium channel protein type 10 subunit alpha
Names
Species
Onychomys torridus (Southern grasshopper mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0DMA5

Entry ID Method Resolution Chain Position Source
AF-P0DMA5-F1 Predicted AlphaFoldDB

No variants for P0DMA5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0DMA5

No associated diseases with P0DMA5

6 regional properties for P0DMA5

Type Name Position InterPro Accession
domain Ion transport domain 129 - 405 IPR005821-1
domain Ion transport domain 666 - 894 IPR005821-2
domain Ion transport domain 1153 - 1429 IPR005821-3
domain Ion transport domain 1478 - 1734 IPR005821-4
domain Sodium ion transport-associated domain 904 - 1149 IPR010526
domain Voltage-gated sodium channel alpha subunit, inactivation gate 1421 - 1473 IPR044564

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • It can be translocated to the cell membrane through association with S100A10
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
voltage-gated sodium channel complex A sodium channel in a cell membrane whose opening is governed by the membrane potential.

2 GO annotations of molecular function

Name Definition
voltage-gated ion channel activity Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated sodium channel activity Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

2 GO annotations of biological process

Name Definition
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
sensory perception of pain The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEFPIGSVGT TNFRRFTPES LAEIEKQIAA HGAAKKARAK HGERKGQDEK PRPQLDLKAC
70 80 90 100 110 120
NQLPRFYGEL PAELVGEPLE DLDPFYSTHR TFMVLNKGRT ISRFSATWAL WLFSPFNLIR
130 140 150 160 170 180
RTAIKVSVHA WFSIFITITI LFNCVCMTQN DLPEKIEYAF TVIYTFEALI KILARGFCLN
190 200 210 220 230 240
EFTYLRDPWN WLDFSVITLA YVGAAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI
250 260 270 280 290 300
HSVRKLADVT ILTVFCLSVF ALVGLQLFKG NLKNKCIKRS TDPHNAYNFS SQMADNFYIK
310 320 330 340 350 360
NGTTEPLLCG NGSDAGHCPS GYICLKTSDN PDFNYTSFDS FAWAFLSLFR LMTQDSWERL
370 380 390 400 410 420
YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE EQNQATIAEI EAKEKKFQEA
430 440 450 460 470 480
LEVLQKEQEV LAALGIDTTS LHSHNGSPLA PKNANERKHR IKSRVSEGST DDNRSPQSDP
490 500 510 520 530 540
YNQRRMSFLG LSSGRRRASH SSVFHFRAPS QDVSFPDGIT DDGVFHGDHE SHRSSLLLAR
550 560 570 580 590 600
GAGQAGPLPR SPLASSPNPG PGHREEGQLT APTGELTTGA PEDLALEAAG QKKNFLSAEY
610 620 630 640 650 660
LNEPFRAQRA MSVVSIMTSV IEELEESKLR CPPCLINLAQ KYLIWECCPK WMKFKMVLFE
670 680 690 700 710 720
LVTDPFAELT ITLCIVVNTI FMAMEHYPMT DAFDAMLQAG NIVFTVFFTM EMAFKIIAFD
730 740 750 760 770 780
PYYYFQKKWN VFDCVIVTVS LLELSIAKKG SLSVLRTFRL LRVFKLAKSW PTLNTLIKII
790 800 810 820 830 840
GNSVGALGNL TFILAIIVFI FALVGKQLLG EDYGCRKDGT ALWNEGQLRW HMCDFFHSFL
850 860 870 880 890 900
VIFRILCGEW IENMWVCMQV SEKSICLILF LTVMVLGNLV VLNLFIALLL NSFSADNLTA
910 920 930 940 950 960
PEDDGEVNNL QVALARTQAF GQRASQAISS YFSSHCRLRW PKVGSQLGVK PSLTSSKAEH
970 980 990 1000 1010 1020
HITADAVNTA VGTSAKPALS GPKEDPRDFI TDANVWVSVP IAEGESDLDE LEEDIEQNSQ
1030 1040 1050 1060 1070 1080
SSWREESPKG QQDQLWQIQR CEDHQVPNSP GSGMSSEDLA SYLGERWKSE ATPQVPAEGV
1090 1100 1110 1120 1130 1140
DDTSSSEGST VDCPDPEEIL KKIPELADDL EEPDDCFTEG CTRHCPCCKV STSKFPWTTG
1150 1160 1170 1180 1190 1200
WQVRKTCYRI VEHSWFESFI IFMILLSSGA LAFEDNYLEQ KPRVKSMLEY TDRVFTFIFV
1210 1220 1230 1240 1250 1260
FEMLLKWVAY GFKKYFTNAW CWLDFLIVNI SLTSLIAKIL DYSDVASLKA LRTLRALRPL
1270 1280 1290 1300 1310 1320
RALSRFEGMR VVVDALVGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKFS RCIDTSNNPF
1330 1340 1350 1360 1370 1380
SVVNSTIVNN KSECRNQNHT GHFFWVNVKV NFDNVAMGYL ALLQVATFKG WMDIMYAAVD
1390 1400 1410 1420 1430 1440
SREINSQPQW EDNLYMYLYF VVFIIFGGFF TLNLFVGVII DNFNQQKKKL GGQDIFMTEE
1450 1460 1470 1480 1490 1500
QKKYYNAMKK LGSKKPQKPI PRPLNKYQGF VFDIVTRQAF DIIIMVLICL NMITMMVETD
1510 1520 1530 1540 1550 1560
GQSEEKTKIL GRINQFFVAV FTGECVMKMF ALRQYYFTNG WNVFDFIVVI LSIGSLVFSA
1570 1580 1590 1600 1610 1620
ILKSLESYFS PTLFRVIRLA RIGRILRLIR AAKGIRTLLF ALMMSLPALF NIGLLLFLVM
1630 1640 1650 1660 1670 1680
FIYSIFGMAS FANVVEEAGI DDMFNFQTFG NSMLCLFQIT TSAGWDGLLS PILNTGPPYC
1690 1700 1710 1720 1730 1740
DPNLSNNNTS KGNCGSPTVG IVFFTTYIII SFLIVVNMYI AVILENFNVA TEESTEPLSE
1750 1760 1770 1780 1790 1800
DDFDMFYETW EKFDPEATQF IAFSALSDFA DTLSGPLRIP KPNQNILIQM DLPLVPGDKI
1810 1820 1830 1840 1850 1860
HCLDILFAFT KNVLGESGEL DSLKTNMEEK FMATNLSKAS YEPIATTLRW KQEDISATVI
1870 1880 1890 1900 1910 1920
QKAYRSYVLQ RSLTLSNPLR VPRAEDDDAP LPGEGYVTFM ANDSGRLPDK SETTSATSFP
1930 1940 1950
PSYDSVTRGL SDRVNISTSN SMHNEDEVTS KEGDSPGPQ