P0DM62

PR
Gene name
Protein name
Astacin-like metalloprotease toxin 5
Names
Loxosceles astacin-like protease 5, LALP5
Species
Loxosceles gaucho (Spider)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

128-186 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0DM62

Entry ID Method Resolution Chain Position Source
AF-P0DM62-F1 Predicted AlphaFoldDB

No variants for P0DM62

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0DM62

No associated diseases with P0DM62

3 regional properties for P0DM62

Type Name Position InterPro Accession
domain Peptidase M12A 1 - 186 IPR001506
domain Peptidase, metallopeptidase 6 - 146 IPR006026
domain Astacin-like metallopeptidase domain 12 - 158 IPR034035

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
toxin activity Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
NAVKYDQQLW PNGEIIYEIS PGLRQYEQLI LEAMRSYEDT TCIKFRRRFD EDDYVNIHVG
70 80 90 100 110 120
DKCYSRVGKS FKGGPQPLSL GNGCTDFGTI LHELGHSVGF DHEHSRTDRD EYLIIHERNI
130 140 150 160 170 180
KNGSEHNFEK LLESKTRTIG PFDYDSIMLY GSYAFSRDTE AVENHGTRRT RTPYEICHSK
RKAELL