P0CX13
PR
Gene name |
COS3 (YML132W, YM4987.03) |
Protein name |
Protein COS3 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YML132W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0CX13
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0CX13-F1 | Predicted | AlphaFoldDB |
97 variants for P0CX13
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-811428 | 16 | S>P | No | SGRP | |
|
s13-7292 s02-811425 |
17 | F>V | No | SGRP | |
|
s02-811400 s13-7317 |
25 | I>T | No | SGRP | |
|
s13-7334 s02-811383 |
31 | L>V | No | SGRP | |
|
s13-7344 s02-811373 |
34 | S>N | No | SGRP | |
|
s02-811371 s13-7346 |
35 | S>G | No | SGRP | |
|
s13-7347 s02-811370 |
35 | S>N | No | SGRP | |
|
s13-7348 s02-811369 |
35 | S>R | No | SGRP | |
|
s13-7351 s02-811366 |
36 | F>L | No | SGRP | |
| s02-811357 | 39 | F>L | No | SGRP | |
| s02-811359 | 39 | F>V | No | SGRP | |
| s02-811358 | 39 | F>Y | No | SGRP | |
| s02-811352 | 41 | Y>S | No | SGRP | |
| s02-811345 | 43 | I>M | No | SGRP | |
| s02-811343 | 44 | Y>S | No | SGRP | |
|
s02-811331 s13-7386 |
48 | A>V | No | SGRP | |
| s02-811305 | 57 | L>V | No | SGRP | |
| s02-811288 | 62 | W>* | No | SGRP | |
| s02-811278 | 66 | S>A | No | SGRP | |
| s13-7449 | 69 | C>F | No | SGRP | |
|
s02-811267 s13-7450 |
69 | C>W | No | SGRP | |
| s02-811266 | 70 | I>V | No | SGRP | |
| s02-811259 | 72 | P>Q | No | SGRP | |
| s02-811257 | 73 | L>F | No | SGRP | |
| s13-7465 | 74 | I>M | No | SGRP | |
|
s02-811229 s13-7488 |
82 | L>R | No | SGRP | |
| s13-7496 | 85 | I>L | No | SGRP | |
| s02-811220 | 85 | I>T | No | SGRP | |
| s13-7496 | 85 | I>V | No | SGRP | |
| s02-811215 | 87 | V>L | No | SGRP | |
| s02-811209 | 89 | V>F | No | SGRP | |
| s13-7515 | 91 | C>F | No | SGRP | |
| s02-811203 | 91 | C>R | No | SGRP | |
| s02-811199 | 92 | G>E | No | SGRP | |
| s13-7517 | 92 | G>R | No | SGRP | |
| s02-811196 | 93 | L>P | No | SGRP | |
| s02-811188 | 96 | K>E | No | SGRP | |
|
s13-7554 s02-811163 |
104 | I>T | No | SGRP | |
|
s13-7571 s02-811146 |
110 | I>V | No | SGRP | |
|
s02-811140 s13-7577 |
112 | E>K | No | SGRP | |
| s02-811136 | 113 | N>S | No | SGRP | |
| s02-811124 | 117 | S>F | No | SGRP | |
| s02-811097 | 126 | A>V | No | SGRP | |
|
s13-7642 s02-811075 |
133 | L>F | No | SGRP | |
|
s13-7654 s02-811063 |
137 | N>K | No | SGRP | |
|
s13-7656 s02-811061 |
138 | V>A | No | SGRP | |
|
s13-7668 s02-811049 |
142 | K>R | No | SGRP | |
| s13-7683 | 147 | N>S | No | SGRP | |
|
s02-811025 s13-7692 |
150 | V>G | No | SGRP | |
| s13-7691 | 150 | V>I | No | SGRP | |
|
s13-7748 s02-810969 |
169 | K>E | No | SGRP | |
| s13-7752 | 170 | A>G | No | SGRP | |
| s13-7774 | 177 | K>N | No | SGRP | |
|
s13-7806 s02-810911 |
188 | G>E | No | SGRP | |
|
s13-7818 s02-810899 |
192 | T>R | No | SGRP | |
| s13-7850 | 203 | T>S | No | SGRP | |
| s02-810845 | 210 | V>A | No | SGRP | |
| s13-7889 | 216 | K>Q | No | SGRP | |
| s13-7932 | 230 | L>S | No | SGRP | |
| s02-810773 | 234 | S>F | No | SGRP | |
| s02-810768 | 236 | I>L | No | SGRP | |
| s02-810763 | 237 | F>L | No | SGRP | |
| s02-810765 | 237 | F>V | No | SGRP | |
| s02-810762 | 238 | M>V | No | SGRP | |
| s02-810757 | 239 | L>F | No | SGRP | |
| s02-810755 | 240 | I>T | No | SGRP | |
| s02-810752 | 241 | P>L | No | SGRP | |
| s02-810744 | 244 | N>Y | No | SGRP | |
| s02-810734 | 247 | C>Y | No | SGRP | |
| s02-810729 | 249 | I>L | No | SGRP | |
| s02-810726 | 250 | Y>H | No | SGRP | |
| s02-810716 | 253 | R>Q | No | SGRP | |
| s02-810713 | 254 | G>E | No | SGRP | |
| s02-810706 | 256 | C>* | No | SGRP | |
| s02-810702 | 258 | L>I | No | SGRP | |
| s02-810688 | 262 | L>F | No | SGRP | |
| s02-810640 | 278 | I>M | No | SGRP | |
| s02-810631 | 281 | L>F | No | SGRP | |
| s02-810627 | 283 | M>V | No | SGRP | |
| s02-810623 | 284 | S>N | No | SGRP | |
| s02-810622 | 284 | S>R | No | SGRP | |
| s02-810596 | 293 | S>L | No | SGRP | |
| s02-810572 | 301 | S>N | No | SGRP | |
| s02-810542 | 311 | R>K | No | SGRP | |
|
s13-8208 s02-810509 |
322 | A>V | No | SGRP | |
|
s13-8214 s02-810503 |
324 | K>R | No | SGRP | |
| s02-810485 | 330 | F>Y | No | SGRP | |
|
s13-8262 s02-810455 |
340 | N>S | No | SGRP | |
| s13-8279 | 346 | V>L | No | SGRP | |
| s02-810414 | 354 | W>R | No | SGRP | |
| s02-810411 | 355 | P>A | No | SGRP | |
| s02-810405 | 357 | P>S | No | SGRP | |
|
s02-810357 s13-8360 |
373 | R>C | No | SGRP | |
| s02-810347 | 376 | V>E | No | SGRP | |
| s02-810345 | 377 | L>F | No | SGRP | |
| s02-810344 | 377 | L>P | No | SGRP | |
| s02-810338 | 379 | V>A | No | SGRP |
No associated diseases with P0CX13
No regional properties for P0CX13
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P0CX13 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| fungal-type vacuole | A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular sodium ion homeostasis | Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. |
| protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKENELKNEK | SVDVLSFKQL | ESQKIVLPQD | LFRSSFTWFC | YEIYKSLAFR | IWMLLWLPLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VWWKLSNNCI | YPLIVSLLVL | FLGPIFVLVI | CGLSRKRSLS | KQLIQFCKEI | TENTPSSDPH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DWEVVAANLN | SYLYENNVWN | TKYFFFNAMV | CQEAFRTTLL | EPFSLKKDKA | AKVKSFKDSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PYIEEALGVY | FTEVEKQWKL | FNTEKSWSPV | GLEDAKLPKE | AYRFKLTWFL | KRISNIFMLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PFLNFLCCIY | VSRGMCLLLR | TLYLGWILFM | LVQGFQNIRV | LIMSMEHKMQ | FLSTIINEQE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SGANGWDEIA | RKMNRYLFEK | KAWKNEEFFF | DGIDCEWFFN | HFFYRVLSAK | KSMWPLPLNV |
| 370 | |||||
| ELWPYIKEAQ | LSRSEVLLV |