P0CS77

PR
Gene name
SSN3 (CDK8, CNBM0820)
Protein name
Serine/threonine-protein kinase SSN3
Names
Cyclin-dependent kinase 8
Species
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
KEGG Pathway
cnb:CNBM0820
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

25-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

233-261 (Activation loop from InterPro)

Target domain

32-396 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P0CS77

Entry ID Method Resolution Chain Position Source
AF-P0CS77-F1 Predicted AlphaFoldDB

No variants for P0CS77

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CS77

No associated diseases with P0CS77

7 regional properties for P0CS77

Type Name Position InterPro Accession
domain Protein kinase domain 240 - 493 IPR000719
domain SH2 domain 120 - 214 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 240 - 488 IPR001245
domain SH3 domain 54 - 116 IPR001452
active_site Tyrosine-protein kinase, active site 355 - 367 IPR008266
binding_site Protein kinase, ATP binding site 246 - 268 IPR017441
domain Tyrosine-protein kinase, catalytic domain 240 - 489 IPR020635

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATIPGGGTI MDPMHLYRAR RDKERRGVLK TYKILGFISS GTYGRVYKAV LLPPPKTASA
70 80 90 100 110 120
KSALPSSTRA ALSLPKDKLP SPSFTEDSDP LNNPEMCMRP GDRPAKRGDV FAIKKFKPDK
130 140 150 160 170 180
EGDVLTYAGI SQSGAREIML NRELHHRNLV SLREVILEDK SIYMVFEYAE HDFLQIIHYH
190 200 210 220 230 240
SQTARASIPP STLRRLLHQL LCGVHFLHSN FVLHRDLKPA NILVTSQGVV KIGDLGLARL
250 260 270 280 290 300
WHKPLAQQGL YGGDKVVVTI WYRAPELILG AKHYTAAVDI WAVGCIYAEL LSLRPIFKGD
310 320 330 340 350 360
EAKMDGKKSL PFQRDQMGKI CEVLGPVKPE QWPGIVHMPE YRTYQATGPY PHSNPLAPWY
370 380 390 400 410 420
HARSNSSEGY DILVKMFEWD PARRITARDA LRHPWFQEEG GVDTKSVFEG SSITYPTRRV
430 440 450 460
THEDNGDAKM GSLPQSMAGG RLPSSSNFRP ASGNIVQPAA RKKARI