P0CS10

PR
Gene name
TRM10
Protein name
tRNA (guanine(9)-N1)-methyltransferase
Names
tRNA methyltransferase 10, tRNA(m1G9)-methyltransferase, tRNA(m1G9)MTase
Species
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KEGG Pathway
cne:CNC05170
EC number
2.1.1.221: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-140 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CS10

Entry ID Method Resolution Chain Position Source
AF-P0CS10-F1 Predicted AlphaFoldDB

No variants for P0CS10

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CS10

No associated diseases with P0CS10

2 regional properties for P0CS10

Type Name Position InterPro Accession
domain tRNA methyltransferase TRMD/TRM10-type domain 278 - 376 IPR016009
domain tRNA methyltransferase TRM10-type domain 131 - 379 IPR028564

Functions

Description
EC Number 2.1.1.221 Methyltransferases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
tRNA (guanine(9)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine.
tRNA (guanine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine.
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
tRNA N1-guanine methylation The process whereby a guanine in tRNA is methylated at position N1 of the guanine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKFHLGLTEA LQEREPNINA SSKDLSPLHF ELYRRSEPIM DIDEESYLNA GPSAPSKIPQ
70 80 90 100 110 120
GGEGDRLQGM SKKAMKRAAK QARLEEIKPL KRAAERERRR QRTAQLAEGY AAGTLSEADK
130 140 150 160 170 180
ELVERRRRVE KERKEAQRRI ESGDQANDWL GGVVIDLGFD DLMTDQEIAS MAQQLGYLYS
190 200 210 220 230 240
SNRTAEKPVR TVIHTTFSPA ASPRLWQRME NFNWHKWSRC HWWEQGLETL KSQLDPSTSI
250 260 270 280 290 300
LSVQSVVSKE TQDKAGIDTK SLLSRLTGPQ VPVDLQAGKH KLVYLSADAE DELLSLSEDE
310 320 330 340 350 360
IYIIGGIVDR NRHKNLCQGK AEQLGIRTAR LPIGTFLEML PTRKVLTVNQ VFDILVKYLH
370 380 390 400 410 420
LGDWAAAFEA VIPIRKYAPG RKTKRAKTET KRNEKEEEEV ECTSAEGEED IGVIEESAEV
DPEDVFSNQ