P0CS08
Gene name |
TRM61 (CNH01430) |
Protein name |
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 |
Names |
tRNA(m1A58)-methyltransferase subunit TRM61, tRNA(m1A58)MTase subunit TRM61 |
Species |
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
KEGG Pathway |
cne:CNH01430 |
EC number |
2.1.1.220: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0CS08
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0CS08-F1 | Predicted | AlphaFoldDB |
No variants for P0CS08
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0CS08 | |||||
No associated diseases with P0CS08
No regional properties for P0CS08
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P0CS08 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.220 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| tRNA (m1A) methyltransferase complex | A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| tRNA (adenine-N1-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDIRKPMFHS | RVHIEAGDIV | ILYMARDNMT | AITITPGETF | HNKYGRYPHD | MLIGQKYGSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IHSPPPHPGY | VHVLRPTPEL | WTLSLPHRTQ | ILYLPDISYI | TMRLGVRVGG | KVIEAGTGSG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SMTHSLSRSV | GPSGQVMSFE | YHRQRFETAL | KEFESHGLTN | VRLQHRNVCK | EGFGDAQGVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVFLDLPAPW | EAIPHAVKAL | RRDIITRICC | FSPCLEQVLK | TVTCLRSEGF | SDISTQEVLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RTHELVTPPP | NTTYLSSISS | VVSYLREHEQ | RKEERRLLQI | KTAKENNRKV | KGIEADDAIP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VEGETGSKRK | LEQPSVTGSD | NAAPANSRPK | TNLLWTEPPN | TLPSTVLTKP | SPEMKGHTSY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LTFAILYPES | VRLSMVAQET | SSRVETPTNI | TKAPETHSQE | THYSEGSEIE | KIGAMTSKEM |
| 430 | |||||
| DDWMKSGSTS | LSI |