P0CR63

PR
Gene name
SNX4 (ATG24, CNBC0900)
Protein name
Sorting nexin-4
Names
Autophagy-related protein 24
Species
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
KEGG Pathway
cnb:CNBC0900
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-98 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CR63

Entry ID Method Resolution Chain Position Source
AF-P0CR63-F1 Predicted AlphaFoldDB

No variants for P0CR63

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CR63

No associated diseases with P0CR63

1 regional properties for P0CR63

Type Name Position InterPro Accession
domain Phox homology 89 - 211 IPR001683

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Preautophagosomal structure membrane ; Peripheral membrane protein
  • Endosome membrane ; Peripheral membrane protein
  • Endosome and other perivacuolar punctate structures
  • Associates to phosphatidylinositol 3-phosphate, necessary for peripheral membrane localization to the perivacuolar punctate structures
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome membrane The lipid bilayer surrounding an endosome.
phagophore assembly site membrane A cellular membrane associated with the phagophore assembly site.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

2 GO annotations of biological process

Name Definition
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDQDGFHSIA WDDAPSSNPP LSAPSPSQSP FEEGFESISP SSAQPPASDQ YEGYDNSKAG
70 80 90 100 110 120
EAGDVGVTLD RRERLGGHEV DGSVWNGKWM DVQVREPAKE HEGSKDMYVS YAVKTETSLP
130 140 150 160 170 180
TFRKPLTVVR RRFQDFVFLR EHLVKNFPAC VVPPIPDKHR LEYIKGDRFS PEFVERRRLD
190 200 210 220 230 240
LQRFADRIAR HPVLQRSQLV NDFLQSTEWS VAKHHHISHP PPESHASLID SLSDTFINAF
250 260 270 280 290 300
SRVRKPDARF VEMTEELERF EEGLTGVERV VGRGKSRVDD LAADYQDMAA AYQGLGYLES
310 320 330 340 350 360
GITEPLNRFA EKMLDFSTLL KHMNNTTIEP FLSSSHSLLS YSATHRNVIK LRDQKQLDFE
370 380 390 400 410 420
ELSAYLSAIV SERDRLAALS SGHTAAPVGL GTYLRDQMDK LRGTDDIHTR RERMRKMDGK
430 440 450 460 470 480
IKELQDAVTL AHETSNAFSE EVIKEHAYFE LEKKQEMKDA LQAYTDGQVE MLQQAMDDWD
490
RIIPLLQRIR VDV