P0CR38

PR
Gene name
SEC23 (CNJ01150)
Protein name
Protein transport protein SEC23
Names
Species
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KEGG Pathway
cne:CNJ01150
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

173-251 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CR38

Entry ID Method Resolution Chain Position Source
AF-P0CR38-F1 Predicted AlphaFoldDB

No variants for P0CR38

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CR38

No associated diseases with P0CR38

1 regional properties for P0CR38

Type Name Position InterPro Accession
domain Ribosomal RNA methyltransferase, FtsJ domain 28 - 214 IPR002877

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.
endoplasmic reticulum exit site An endoplasmic reticulum part at which COPII-coated vesicles are produced.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
COPII-coated vesicle cargo loading The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNFEDIEDKD GVRFSWNVWP SSRLEATRTV VPISALYTPL KEREDLPPVM YEPVTCKGSS
70 80 90 100 110 120
CKAILNPYCQ VDVRGKMWIC PFCLQRNPFP PHYHQDLSPN NLPPELLPKF TTIEYTLSRP
130 140 150 160 170 180
AQIPPIFLYV VDTCVDEDEL KALKETLVVS LSLLPPNALV GLITYGTMAM VHELAYADCP
190 200 210 220 230 240
KAYVFRGSKD YQPKQIADML GLNPSNRPIQ PVRPGQPMPA PAASKFLMPV QACEFQLTNI
250 260 270 280 290 300
LEQLQRDPWP VEQDKRPLRC TGVALSVAVS LLETAFPNTG ARIMLFSGGP ATDGPGMVVG
310 320 330 340 350 360
PELREPIRSH HDIDRDSVKH FKRASKFYEA LSKRASVNGH AIDIYAGCLD QVGLLEMKSL
370 380 390 400 410 420
TNATNGVMTI SDSFMTAIFK QSFLRTLGKD EQGYLKMGFN ATYDVLTTKE LKISGVIGHV
430 440 450 460 470 480
ISANKKSSCV GETEIGIGQT SAWKVCSLTP KSTLATYFEV VTPAGQALTP NQSGLIQFVT
490 500 510 520 530 540
HYQHSSGQYR LRVTTVSRVF QEGGHPSIAA SFDQEAAAVL MARIAVFKAE IDDSPDVLRW
550 560 570 580 590 600
LDRMLIRLCQ KFADYRKEDP TSFQLSPNFS IYPQFMFHLR RSQFLQVFNN SPDETAFYRH
610 620 630 640 650 660
VLNDSDVNNS LIMIQPTLMS YGFDSEPHPV LLDSVSIRPD VILLLDTFFH ILIFHGETIA
670 680 690 700 710 720
QWRKANYQEQ EDYANFKELL EAPIGDAQEL LEDRMPIPRY VVCDQGGSQA RFLLSKLNPS
730 740 750 760
TTHMSGSNYG AGPAGGQAIF TDDVSLQVFM EHLKRLAVGA STS