P0CP93

PR
Gene name
CWC27 (CNBJ1160)
Protein name
Peptidyl-prolyl isomerase CWC27
Names
PPIase CWC27, Rotamase CWC27
Species
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
KEGG Pathway
cnb:CNBJ1160
EC number
5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

218-423 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CP93

Entry ID Method Resolution Chain Position Source
AF-P0CP93-F1 Predicted AlphaFoldDB

No variants for P0CP93

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CP93

No associated diseases with P0CP93

1 regional properties for P0CP93

Type Name Position InterPro Accession
domain Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain 15 - 167 IPR002130

Functions

Description
EC Number 5.2.1.8 Cis-trans isomerases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.

1 GO annotations of molecular function

Name Definition
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

3 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
protein peptidyl-prolyl isomerization The modification of a protein by cis-trans isomerization of a proline residue.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNLYATEPA TNGKVIIDTT AGEIEVELWG KECPKAVRNF LALTMEGYYD GVIFHRVVPG
70 80 90 100 110 120
FIIQSGDPTG TGMGGESFYG EPFEDEIHGR LKFNRRGLLG MANNGSRNSN TSQFFITLDA
130 140 150 160 170 180
APELTNKHTM FGKIVGNTIF NVLNIGNLDT DKEERPLIPP KIRRIHIIEN PFDDIVPRIT
190 200 210 220 230 240
AEEKKAQQKA KLEAKKDMEQ RERRAKAKKN TGLLSFGDSE EIPEEEVTVK KKSMTRQDLV
250 260 270 280 290 300
DPSEAEHTKS KTSKMTETFV NIPPSLKDLG KSRENEASEE KKAVDLKNIR AQHEREKAGG
310 320 330 340 350 360
SAARQAEIKR MEEDLRRLKK RSGSVSDSES DSSSRARRKG PSYLEQELAK YASKRGRAAM
370 380 390 400 410 420
KAGNKRGRRD EEEDVLTEMR KFSKRVMQAG DEPEEEQAEE IEEGEAKEEG TGIGAAMAEE
430 440 450 460 470 480
EGGIEVDDDV GWLTHKLKFQ VDDKELTRRA EDEYAVIDPR AKARDLLGKP DKKKLKGNPN
490
RRTVRNSGRN R