P0CP92
Gene name |
CWC27 (CNJ02320) |
Protein name |
Peptidyl-prolyl isomerase CWC27 |
Names |
PPIase CWC27, Rotamase CWC27 |
Species |
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
KEGG Pathway |
cne:CNJ02320 |
EC number |
5.2.1.8: Cis-trans isomerases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0CP92
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0CP92-F1 | Predicted | AlphaFoldDB |
No variants for P0CP92
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0CP92 | |||||
No associated diseases with P0CP92
1 regional properties for P0CP92
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain | 15 - 167 | IPR002130 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.2.1.8 | Cis-trans isomerases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| peptidyl-prolyl cis-trans isomerase activity | Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| protein peptidyl-prolyl isomerization | The modification of a protein by cis-trans isomerization of a proline residue. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNLYATEPA | TNGKVIIDTT | AGEIEVELWG | KECPKAVRNF | LALTMEGYYD | GVIFHRVVPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FIIQSGDPTG | TGMGGESFYG | EPFEDEIHGR | LKFNRRGLLG | MANNGSRNSN | TSQFFITLDA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| APELTNKHTM | FGKIVGNTIF | NVLNIGNLDT | DKEERPLIPP | KIRRIHIIEN | PFDDIVPRIT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AEEKKAQQKA | KLEAKKDMEQ | RERRAKAKKN | TGLLSFGDSE | EIPEEEVTVK | KKSMTRQDLV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DPSEAEHTKS | KTSKMTETFV | NIPPSLKDLG | KSRENEASEE | KKAVDLKNIR | AQHEREKAGG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SAARQAEIKR | MEEDLRRLKK | RSGSVSDSES | DSSSRARRKG | PSYLEQELAK | YASKRGRAAM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KAGNKRGRRD | EEEDVLTEMR | KFSKRVMQAG | DEPEEEQAEE | IEEGEAKEEG | TGIGAAMAEE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EGGIEVDDDV | GWLTHKLKFQ | VDDKELTRRA | EDEYAVIDPR | AKARDLLGKP | DKKKLKGNPN |
| 490 | |||||
| RRTVRNSGRN | R |