P0CP41

PR
Gene name
NUF2 (CNBA6390)
Protein name
Probable kinetochore protein NUF2
Names
Species
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
KEGG Pathway
cnb:CNBA6390
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

43-119 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CP41

Entry ID Method Resolution Chain Position Source
AF-P0CP41-F1 Predicted AlphaFoldDB

No variants for P0CP41

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CP41

No associated diseases with P0CP41

2 regional properties for P0CP41

Type Name Position InterPro Accession
domain Kinetochore protein Nuf2, N-terminal 13 - 165 IPR005549
domain Nuf2, DHR10-like domain 282 - 395 IPR041112

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, centromere, kinetochore
  • Associated with kinetochores
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Ndc80 complex An outer kinetochore protein complex that is part of the KMN kinetochore network (also known as the NMS complex) providing the platform with which the plus ends of spindle microtubules directly interact to form stable kinetochore-microtubule attachments. A common subunit nomenclature is used from yeast to human: Ndc80, Nuf2, Spc24, and Spc25.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQQNRRVQQ NTAAFPLLTA HDILECLAAL DIPAQMEDLT KPTAQSTQSI YGSLLEVLMG
70 80 90 100 110 120
ASINSIEGPK QALLGMMEYK VLSFRSMKRT QINLSRQEMY SDTLQFMMFF KHCRRLALLC
130 140 150 160 170 180
GIPDFAISDL ARPDANRLRK VLSGIMNFAK FRDERMQTQA RFQENLQKHQ KKAVDLRRKT
190 200 210 220 230 240
EELETQFQEI TARNAAERPQ SEQAQKRNEL LKSELLELNS QRLKEVQEYE ELKKERQTLL
250 260 270 280 290 300
EQVNHNNRIV TQLELQIGSA KSRLVQSPDR IKRHISEMSF AIQSEKAKLA SFQQKARELT
310 320 330 340 350 360
NRLEVIGALE VDLRGLIDLE HSIQDQRAKT EEAKRSKSAL EARLEGRQIE SQGLAAKLEQ
370 380 390 400 410 420
LQRQLQNASH KLARQEETRK GMRERGARRI DELKAEYKVR ARERGEWQKQ RDDLLAEQKE
430 440 450 460
LESEMAAFVT KHENEINEFL HAYWTMRRQA EDYMNTMTVK LGLQVQL