P0CO08

PR
Gene name
SYF1 (CNE01310)
Protein name
Pre-mRNA-splicing factor SYF1
Names
Species
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KEGG Pathway
cne:CNE01310
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

39-173 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CO08

Entry ID Method Resolution Chain Position Source
AF-P0CO08-F1 Predicted AlphaFoldDB

No variants for P0CO08

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CO08

No associated diseases with P0CO08

14 regional properties for P0CO08

Type Name Position InterPro Accession
repeat HAT (Half-A-TPR) repeat 90 - 122 IPR003107-1
repeat HAT (Half-A-TPR) repeat 214 - 248 IPR003107-2
repeat HAT (Half-A-TPR) repeat 452 - 487 IPR003107-3
repeat HAT (Half-A-TPR) repeat 610 - 646 IPR003107-4
repeat HAT (Half-A-TPR) repeat 648 - 698 IPR003107-5
repeat HAT (Half-A-TPR) repeat 700 - 732 IPR003107-6
repeat HAT (Half-A-TPR) repeat 734 - 768 IPR003107-7
repeat HAT (Half-A-TPR) repeat 773 - 807 IPR003107-8
repeat HAT (Half-A-TPR) repeat 845 - 879 IPR003107-9
repeat HAT (Half-A-TPR) repeat 881 - 915 IPR003107-10
repeat Tetratricopeptide repeat 438 - 471 IPR019734-1
repeat Tetratricopeptide repeat 634 - 667 IPR019734-2
repeat Tetratricopeptide repeat 759 - 792 IPR019734-3
repeat Tetratricopeptide repeat 867 - 900 IPR019734-4

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
post-mRNA release spliceosomal complex A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5.
Prp19 complex A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
U2-type catalytic step 2 spliceosome A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
generation of catalytic spliceosome for first transesterification step Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASTSLVDSL TSHFPLTLPI PTPITHPHLI PSADLPVEED LLHNPENLRS WLSYIHNVKE
70 80 90 100 110 120
KIAADEPAKG GVLSPEEEIL GPLASKNARD GLQRLVSIYE RAIAVFPTSY KLWKAYYLTR
130 140 150 160 170 180
QSYVLGELTN DAKEARSQQA KRGAAYKTNV RELLDGAEEA HEWTGGLDPV VGYAEWRSLV
190 200 210 220 230 240
ATGERMIMCL PNLPIPWLLH LGVLLHPKCP SVFKNGSYAR RAFDRALRTL PPSLHGRVWG
250 260 270 280 290 300
LYLRWAEIVG GDAGERVWRR YLKVDPSLTE RHITYLLEAE EPRPLAAAKY LLSIARRAQQ
310 320 330 340 350 360
NLYSSLEGKS PYQLFVDFLE LVEKYADQIG MDEEGTLELQ RTKRAVEEKV DGEQPQVEGQ
370 380 390 400 410 420
EQQPQEEPAS INGRLMRIAG PPVPLEQGKL FKPVNAASAQ APTQLTYDED TDPSNPRLLD
430 440 450 460 470 480
VEGIVERDGL QVYKDQAGRL WTGLATYWIK RGEFERATAT FERGLAAVVT IRDFTQIFDA
490 500 510 520 530 540
YAEFSETMIS TLMDALADED NLEDEDFDAE ETEQELDERM KSFEELMDRR PFLVNDVLLR
550 560 570 580 590 600
RNPNEVVEWE KRIALHGDDD AKVVEAYVKA LDTINPRKAT GPLYPLYVNF AKFYEEGGSK
610 620 630 640 650 660
DDNGEPRNEP DLEQARKIFE RATKVPFKAV DELAEVWCEW AEMELRNENY EEAIRLMQRA
670 680 690 700 710 720
TTVPKNTKIN YYDDNIPPQS RLFKSLKLWS YYSDLEESIG TVESTKAVYD KIMELKIANA
730 740 750 760 770 780
QVIVNYATFL EENKYFEESF KVYERGIELF HFPIAFEIWN IYLSKFVKRY GGKKLERARD
790 800 810 820 830 840
LFEQALENCP EKFCKPLYLM YAKLEEEHGL AKRAMGIYDR AASTVQDSDK FEMYTIYIAK
850 860 870 880 890 900
ATANFGLPAT RPIYERALES LPDKQTAEMC RRFARMERKL GEIDRARAIY AHASQFCDPR
910 920 930 940 950 960
IEPEFWQEWN DFEIETGSED TFREMLRIKR AVQASFNTET SFIAAQAAAA SKGTEKPTDT
970 980 990 1000 1010 1020
SAQEAQDAAD PMAAMERELS AAGADGARKG GAPAFVASTL NKTNANGIDE GGEETGEMAN
1030
PDAIVMDEDE F