P0CN97

PR
Gene name
GPA1 (CNBH0490)
Protein name
Guanine nucleotide-binding protein subunit alpha
Names
Species
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
KEGG Pathway
cnb:CNBH0490
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-135 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CN97

Entry ID Method Resolution Chain Position Source
AF-P0CN97-F1 Predicted AlphaFoldDB

No variants for P0CN97

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CN97

No associated diseases with P0CN97

No regional properties for P0CN97

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P0CN97

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
heterotrimeric G-protein complex Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.

5 GO annotations of molecular function

Name Definition
G protein-coupled receptor binding Binding to a G protein-coupled receptor.
G-protein beta/gamma-subunit complex binding Binding to a complex of G-protein beta/gamma subunits.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGGCMSTPEA PKKTAETKQV PSTSTSSRPP QASTSATATA AGAGTSAANG TANGIKGDTT
70 80 90 100 110 120
ATNRVGTSGG QGLAAALAST EPPGAQDSKG NKDRSNQIDR QLEDDQKKFR KECKILLLGS
130 140 150 160 170 180
GESGKSTIVK QMKIIHQNGY SKDELLSFRG VIYKNVLDSA QALIMAMRKI GVDPEDANNR
190 200 210 220 230 240
SYADRILEYR MDAGLDAVIP SEILYNIESL WHDPVIPSVM DRSSEFYLMD SATYFFANIR
250 260 270 280 290 300
KIAGPDYVPD EADVLRARTK TTGISETRFN MGQLSIHMFD VGGQRSERKK WIHCFEAVTS
310 320 330 340 350 360
IIFCVALSEY DQVLLEESGQ NRMQESLVLF ESVINSRWFL RTSVILFLNK IDLFKQKLPK
370 380 390 400 410 420
VPLVQYFPEY TGGADINKAA KYILWRFTQT NRARLSVYPH LTQATDTSNI RLVFAAVKET
430
ILQNALRDSG IL