P0CN96
Gene name |
GPA1 (CNI00520) |
Protein name |
Guanine nucleotide-binding protein subunit alpha |
Names |
|
Species |
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
KEGG Pathway |
cne:CNI00520 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0CN96
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0CN96-F1 | Predicted | AlphaFoldDB |
1 variants for P0CN96
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 373 | G>MRRN | strain: ATCC 42163 / CBS 7823 / 68-5 [UniProt] | No |
No associated diseases with P0CN96
No regional properties for P0CN96
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P0CN96 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| heterotrimeric G-protein complex | Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor binding | Binding to a G protein-coupled receptor. |
| G-protein beta/gamma-subunit complex binding | Binding to a complex of G-protein beta/gamma subunits. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP). |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGGCMSTPEA | PKKTAETKQV | PSTSTSSRPP | QASTSATATA | AGAGTSAANG | TANGIKGDTT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ATNRVGTSGG | QGLAAALAST | EPPGAQDSKG | NKDRSNQIDR | QLEDDQKKFR | KECKILLLGS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GESGKSTIVK | QMKIIHQNGY | SKDELLSFRG | VIYKNVLDSA | QALIMAMRKI | GVDPEDANNR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SYADRILEYR | MDAGLDAVIP | SEILYNIESL | WHDPVIPSVM | DRSSEFYLMD | SATYFFANIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KIAGPDYVPD | EADVLRARTK | TTGISETRFN | MGQLSIHMFD | VGGQRSERKK | WIHCFEAVTS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IIFCVALSEY | DQVLLEESGQ | NRMQESLVLF | ESVINSRWFL | RTSVILFLNK | IDLFKQKLPK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VPLVQYFPEY | TGGADINKAA | KYILWRFTQT | NRARLSVYPH | LTQATDTSNI | RLVFAAVKET |
| 430 | |||||
| ILQNALRDSG | IL |