P0CN45

PR
Gene name
PRT1
Protein name
Eukaryotic translation initiation factor 3 subunit B
Names
eIF3b, Eukaryotic translation initiation factor 3 90 kDa subunit homolog, eIF3 p90, Translation initiation factor eIF3 p90 subunit homolog
Species
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
KEGG Pathway
cnb:CNBD0640
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CN45

Entry ID Method Resolution Chain Position Source
AF-P0CN45-F1 Predicted AlphaFoldDB

No variants for P0CN45

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CN45

No associated diseases with P0CN45

2 regional properties for P0CN45

Type Name Position InterPro Accession
domain RNA recognition motif domain 42 - 129 IPR000504
domain Translation initiation factor, beta propellor-like domain 424 - 647 IPR013979

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex, eIF3e An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.
eukaryotic translation initiation factor 3 complex, eIF3m An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m.

3 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
translation initiation factor binding Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.

1 GO annotations of biological process

Name Definition
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSAADLDYFS EDEQREIEAE LDTGFKDIEE KYAVTAQKGF ETMLVVDNIP IVDGSKKQRL
70 80 90 100 110 120
LERLRQTFAK VGAPIEEESI DMPWNAAAGT NKGFVFLTYP DVKEAENAVH TLDGVSFGKN
130 140 150 160 170 180
VLHVNRFGDI QRFASMPVGE GDLPSGWKEK EYIEKDYLRN WLGDIAGRDQ YVTFWETEVT
190 200 210 220 230 240
VWWNGRNGTA EALKGPDGKP VKNSKWGELY LQWSTMGTYL ASLHRVGVAL WSGPKLDGPI
250 260 270 280 290 300
GVNVLRFTHP NVRLIQFSPC ENYLVTWSED PLPNYENHPN AALRDTFGPE DEGNQYVIWD
310 320 330 340 350 360
IKTTRVLRTF PGDKSAIGVD DTQSRMSWPT FKWSADDSYI AKCNVGAGIS VYELPTMGLL
370 380 390 400 410 420
DRKSIKIEGV QDFEWCPMSQ KDLIARQEGK GKECVLAFWT PEAQNQPARV NIMAVPSRTI
430 440 450 460 470 480
LRSKNLFNVS ECKFYWQSQG DFLCVKVDRH ARKAKSKKAT SCNLEIFRMR EKDYPVEVLE
490 500 510 520 530 540
FKDYVPQFAW EPSGTRFAIV LQAETNLPSV SGASTKYSID FYQLDSKKGD FIAIKHLDSK
550 560 570 580 590 600
MANTLVWSPK GRHIALATIG SSSKYDIEFW DLDFTIDERR EAAELGANVT MLGTGEHYGI
610 620 630 640 650 660
TEIAWDPSGR YIATSASTWR QSPEPGFSIW DFKGQQLLHE SRDRFKQFLW RPRPPTLLSK
670 680 690 700 710 720
DQIKKVRKEL REYSRQFDEE DAAEENRGSA EKLAQRRREI GEWNAWRTRN NDRLAFEREN
730 740 750
RGKSKAKIDV KGQEARVEEW VEELIDETEE LSM